Schulze G, Bürgel P
Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):143-7. doi: 10.1007/BF00508621.
A method is described which allows to measure thermoregulatory effective conditioned behaviour in rats. This method makes it possible to vary the preset ambient temperature (Ta) in a wide range. The results only deal with subnormal Ta (normal housing temperature 23 degrees C). Rats are able to acquire a conditioned behaviour additional to inborn behaviour which is adequate to contribute to thermal homoeostasis. Exposed to -4 degrees C adult animals adjusted their mean Ta to +4 degrees C, old animals to +8 degrees C. A dose of 40 micromol/kg Phentolamine caused adult rats to adjust mean temperature to +9 degrees C, old rats to +13.5 degrees C. But even this increased behavioural activity did not prevent the hypothermic effect of the drug totally. Core temperature in adult animals dropped by 0.8 degrees C, in old animals by 1.4 degrees C.
本文描述了一种测量大鼠体温调节有效条件行为的方法。该方法能够在很宽的范围内改变预设的环境温度（Ta）。研究结果仅涉及低于正常水平的Ta（正常饲养温度为23摄氏度）。大鼠能够习得一种除先天行为之外的条件行为，这种行为有助于维持热稳态。成年动物暴露于-4摄氏度环境时，会将平均Ta调节至+4摄氏度，老年动物则调节至+8摄氏度。40微摩尔/千克剂量的酚妥拉明使成年大鼠将平均体温调节至+9摄氏度，老年大鼠调节至+13.5摄氏度。但即便这种行为活动增强，也未能完全阻止该药物的降温作用。成年动物的核心体温下降了0.8摄氏度，老年动物下降了1.4摄氏度。
