Flammer Keven, Massey J Gregory, Meek Caroline J, Papich Mark G
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA.
Department of Molecular Biosciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA.
J Avian Med Surg. 2013 Sep;27(3):187-93. doi: 10.1647/1082-6742-27.3.187.
Doxycycline hyclate was mixed with soybean oil and then added to a low-fat pelleted diet that contained approximately 2.4% fat, which produced a final diet that contained a calculated 6.4% fat and 300 mg doxycycline per kilogram of diet. The medicated diet was fed to 9 healthy adult cockatiels (Nymphicus hollandicus) for 47 days; a control group of 6 birds received the identical diet without doxycycline. Trough doxycycline plasma concentrations were measured 7 times during treatment and ranged from 0.98 to 3.83 microg/mL with an overall median of 2.09 microg/ mL. The birds were observed daily, weighed, and examined at least weekly, and selected plasma biochemical parameters were measured before treatment and at days 21 and 42. No adverse effects were noted, except one treatment bird became obese. This medicated diet may be suitable for treating spiral bacteria and Chlamydophila psittaci infections in cockatiels that will consume a pelleted diet.
将盐酸多西环素与大豆油混合，然后添加到一种低脂颗粒饲料中，该饲料含有约2.4%的脂肪，最终制成的饲料含有经计算的6.4%的脂肪和每千克饲料300毫克的盐酸多西环素。将这种加药饲料喂给9只健康的成年鸡尾鹦鹉（虎皮鹦鹉），持续47天；6只鸟组成的对照组接受不含多西环素的相同饲料。在治疗期间7次测量血浆多西环素谷浓度，范围为0.98至3.83微克/毫升，总体中位数为2.09微克/毫升。每天观察这些鸟，称重，并至少每周检查一次，在治疗前以及第21天和第42天测量选定的血浆生化参数。除了一只接受治疗的鸟变得肥胖外，未观察到不良反应。这种加药饲料可能适用于治疗愿意食用颗粒饲料的鸡尾鹦鹉中的螺旋菌和鹦鹉衣原体感染。
