Pilloni A, Camargo P M, Carere M, Carranza F A
University of Rome Tor Vergata, School of Dentistry, Department of Periodontics, Italy.
J Periodontol. 1998 Jul;69(7):791-7. doi: 10.1902/jop.1998.69.7.791.
The purpose of this study was to compare probing depth resolution achieved by gingivectomy and periodontal flap techniques in the treatment of cyclosporine A- and nifedipine-induced gingival enlargement. Ten kidney transplant patients who were receiving cyclosporine A and nifedipine for at least 6 months participated in the study. Five patients were randomly assigned to the gingivectomy group and 5 patients to the periodontal flap group. Only anterior segments of the oral cavity (canine to canine) were surgically treated. Clinical measurements, including probing depths, plaque index, and gingival sulcus index, were taken at baseline, 6 weeks, 6 months, and 1 year. Results showed that probing depths, while similar for both groups in the first 6 weeks of the study, were significantly shallower for the periodontal flap group when compared to the gingivectomy group at 6 months (2.48 +/- 0.34 mm versus 4.87 +/- 0.79 mm, respectively) and 1 year (322 +/- 0.65 mm versus 6.40 +/- 1.02 mm, respectively). Within its limitations, this study suggests that the pocket reduction achieved by the periodontal flap may be sustained for longer periods of time than by the gingivectomy technique in the treatment of cyclosporine A- and nifedipine-induced gingival enlargement.
本研究的目的是比较牙龈切除术和牙周翻瓣术在治疗环孢素A和硝苯地平引起的牙龈增生时所达到的探诊深度分辨率。10名接受环孢素A和硝苯地平治疗至少6个月的肾移植患者参与了该研究。5名患者被随机分配到牙龈切除术组，5名患者被分配到牙周翻瓣术组。仅对口腔前部（尖牙至尖牙）进行手术治疗。在基线、6周、6个月和1年时进行临床测量，包括探诊深度、菌斑指数和龈沟指数。结果显示，在研究的前6周，两组的探诊深度相似，但在6个月时（分别为2.48±0.34mm和4.87±0.79mm）和1年时（分别为3.22±0.65mm和6.40±1.02mm），牙周翻瓣术组的探诊深度明显比牙龈切除术组浅。在其局限性范围内，本研究表明，在治疗环孢素A和硝苯地平引起的牙龈增生时，牙周翻瓣术实现的牙周袋深度减小可能比牙龈切除术技术维持更长时间。
