Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
J Sex Med. 2014 Jan;11(1):222-9. doi: 10.1111/jsm.12366. Epub 2013 Oct 31.
Our knowledge concerning the effects of testosterone (T) therapy on the skin of trans men (female-to-male transsexuals) is scarce.
The aim of this study was to evaluate the short- and long-term clinical effects of T treatment on the skin of trans men.
We conducted a prospective intervention study in 20 hormone naive trans men and a cross-sectional study in 50 trans men with an average of 10 years on T therapy.
Acne lesions were assessed using the Gradual Acne Grading Scale, hair patterns using the Ferriman and Gallwey classification (F&G), and androgenetic alopecia using the Norwood Hamilton Scale.
T treatment increased facial and body hair growth. The F&G score increased progressively from a median value of 0.5 at baseline to a value of 12 after 12 months of T administration. After long-term T treatment, all but one trans man achieved an F&G score indicative of hirsutism in women, with a median value of 24. Only one trans man acquired mild frontotemporal hair loss during the first year of T treatment, whereas 32.7% of trans men had mild frontotemporal hair loss and 31% had moderate to severe androgenetic alopecia after long-term T therapy. The presence and severity of acne increased during the first year of T therapy, and peaked at 6 months. After long-term T treatment, most participants had no or mild acne lesions (93.9%). Dermatological outcome was not demonstrably related to individual serum T or dihydrotestosterone levels.
T treatment increased facial and body hair in a time-dependent manner. The prevalence and severity of acne in the majority of trans men peaked 6 months after beginning T therapy. Severe skin problems were absent after short- and long-term T treatment.
我们对睾丸激素（T）治疗对跨性别男性（男变女变性者）皮肤的影响知之甚少。
本研究旨在评估 T 治疗对跨性别男性皮肤的短期和长期临床影响。
我们对 20 名激素初治的跨性别男性进行了前瞻性干预研究，并对 50 名接受 T 治疗平均 10 年的跨性别男性进行了横断面研究。
痤疮病变采用逐渐痤疮分级量表评估，毛发模式采用 Ferriman 和 Gallwey 分类（F&G），雄激素性脱发采用 Norwood Hamilton 量表。
T 治疗增加了面部和身体毛发的生长。F&G 评分从基线时的中位数 0.5 逐渐增加到 T 治疗 12 个月后的 12。长期 T 治疗后，除 1 名跨性别男性外，所有男性均出现女性多毛症的 F&G 评分，中位数为 24。仅 1 名跨性别男性在 T 治疗的第一年出现轻度额颞部脱发，而 32.7%的跨性别男性在长期 T 治疗后出现轻度额颞部脱发，31%出现中度至重度雄激素性脱发。T 治疗的第一年痤疮的发生和严重程度增加，并在 6 个月时达到高峰。长期 T 治疗后，大多数参与者无或轻度痤疮（93.9%）。皮肤学结局与个体血清 T 或二氢睾酮水平无明显相关性。
T 治疗以时间依赖的方式增加面部和身体毛发。大多数跨性别男性的痤疮发生率和严重程度在开始 T 治疗后 6 个月达到高峰。短期和长期 T 治疗后没有严重的皮肤问题。
