Internal Medicine Service, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
BMC Gastroenterol. 2013 Dec 17;13:172. doi: 10.1186/1471-230X-13-172.
Allopurinol is a frequently prescribed drug. In inflammatory bowel disease patients who shunt thiopurine metabolism towards more toxic and less desirable pathways, allopurinol is proving to be an effective add on therapy with good resultant disease control and less treatment side effects. As many such patients are young, the potential for pregnant women to be exposed to allopurinol is increasing. The safety of allopurinol in pregnancy is not known however.
We report three cases of safe use of allopurinol in pregnancy for women with inflammatory bowel disease. This included 2 patients with ulcerative colitis and 1 patient with fistulising Crohn's disease. Allopurinol was used throughout pregnancy in all patients. All 3 pregnancies resulted in normal healthy babies born at term by Caesarean section.
It is important to evaluate and document the safety of allopurinol during pregnancy, as it is finding new roles in young patients. These three cases add significantly to the very limited data on allopurinol use in pregnancy. We encourage reporting of all cases of allopurinol use in pregnant patients and suggest an allopurinol pregnancy registry to document drug exposures and outcomes.
别嘌醇是一种常用药物。在分流巯嘌呤代谢为更具毒性和不理想途径的炎症性肠病患者中，别嘌醇被证明是一种有效的附加治疗方法，具有良好的疾病控制效果和较少的治疗副作用。由于许多此类患者较为年轻，孕妇接触别嘌醇的可能性正在增加。然而，别嘌醇在怀孕期间的安全性尚不清楚。
我们报告了 3 例炎症性肠病女性患者在怀孕期间安全使用别嘌醇的情况。其中 2 例为溃疡性结肠炎患者，1 例为瘘管性克罗恩病患者。所有患者均在整个孕期使用别嘌醇。所有 3 例妊娠均通过剖宫产足月分娩出正常健康婴儿。
评估和记录怀孕期间别嘌醇的安全性非常重要，因为它在年轻患者中找到了新的作用。这 3 例病例大大增加了有关别嘌醇在怀孕期间使用的非常有限的数据。我们鼓励报告所有在孕妇中使用别嘌醇的病例，并建议建立别嘌醇妊娠登记处，以记录药物暴露和结果。
