Sexual Medicine and Andrology Unit Department of Experimental, Clinical, and Biomedical Sciences, University of Florence, Florence, Italy; Endocrinology Unit, Medical Department, Azienda Usl Bologna Maggiore-Bellaria Hospital, Bologna, Italy.
J Sex Med. 2014 Jan;11(1):240-53. doi: 10.1111/jsm.12327. Epub 2013 Oct 29.
We previously reported that in male patients consulting for sexual dysfunction, low prolactin (PRL) levels were associated with metabolic syndrome (MetS), arteriogenic erectile dysfunction, and incident major cardiovascular events.
The aim of this study is to assess the clinical associations of PRL levels in the European Male Ageing Study (EMAS).
EMAS is a prospective, observational cohort of community-dwelling men aged 40-79 years old (mean age 60 ± 11 years old). PRL was available for 2,948 men.
Different parameters were evaluated including the Short Form-36 questionnaire, Becks Depression Inventory, the Adverse Life Events Scale, the Physical Activity Scale for the Elderly, and the EMAS sexual function questionnaire (EMAS-SFQ).
After the adjustment for confounders, PRL levels were inversely related with worsening of sexual function as compared with the previous year, as derived from change in sexual functioning domain of the EMAS-SFQ (adj. r = -0.043; P = 0.029). The strongest correlation (Wald = 6.840; P = 0.009) was observed between lower PRL levels and reduced enjoyment of orgasmic experiences. Furthermore, an inverse relationship between PRL levels and stressful life events or depressive symptoms was observed. Low PRL was also negatively associated with an unhealthy metabolic phenotype as well as with the MetS (Wald = 5.229; P = 0.022). In line with these data, low PRL was associated with a lower level of physical activity and feeling unhealthier.
Low PRL is related to several metabolic, psychological, and sexual unhealthy characteristics in European men. Checking PRL might be useful to stratify men for cardiovascular risk and to encourage appropriate lifestyle changes.
我们之前报道过，在因性功能障碍就诊的男性患者中，低催乳素（PRL）水平与代谢综合征（MetS）、动脉性勃起功能障碍和主要心血管事件的发生有关。
本研究旨在评估催乳素（PRL）水平在欧洲男性衰老研究（EMAS）中的临床相关性。
EMAS 是一项针对社区居住的 40-79 岁男性（平均年龄 60±11 岁）的前瞻性观察性队列研究。共有 2948 名男性的 PRL 数据可用。
评估了包括 36 项简短健康调查问卷（Short Form-36 questionnaire）、贝克抑郁量表（Becks Depression Inventory）、生活不良事件量表（Adverse Life Events Scale）、老年人体力活动量表（Physical Activity Scale for the Elderly）和 EMAS 性功能问卷（EMAS-SFQ）在内的不同参数。
在调整混杂因素后，PRL 水平与性功能较前一年恶化呈负相关，这是根据 EMAS-SFQ 性功能领域的变化得出的（调整后 r=-0.043，P=0.029）。PRL 水平与性高潮体验减少之间存在最强的相关性（Wald=6.840，P=0.009）。此外，还观察到 PRL 水平与生活压力事件或抑郁症状之间存在负相关。低 PRL 也与不健康的代谢表型和代谢综合征（MetS）呈负相关（Wald=5.229，P=0.022）。与这些数据一致的是，低 PRL 与较低的体力活动水平和感觉不健康有关。
低 PRL 与欧洲男性的多种代谢、心理和性功能不健康特征相关。检查 PRL 可能有助于对男性进行心血管风险分层，并鼓励适当的生活方式改变。
