Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Hampton House/Room 797, Baltimore, MD 21205
J Clin Psychiatry. 2014 Feb;75(2):169-77. doi: 10.4088/JCP.13m08443.
To assess the trend in long-term use of antidepressants by persons aged ≥ 18 years, and the correlates of such use, in the United States from 1999 to 2010.
We examined trends in duration of antidepressant use and correlates of long-term use in data from 6 waves of the cross-sectional National Health and Nutrition Examination Survey (N = 35,379), a representative survey of the general population.
The overall prevalence of antidepressant use increased from 6.5% in 1999-2000 to 10.4% in 2009-2010 (odds ratio [OR] = 1.54; 95% CI, 1.31-1.81; P < .001). This included an increase from 3.0% to 6.9% in long-term use (≥ 24 months; OR = 2.12; 95% CI, 1.75-2.57; P < .001). Medium-term (6 to < 24 months; from 1.3% to 1.6%) and short-term use (< 6 months; from 2.2% to 1.8%) of antidepressants did not change appreciably in this period. The increasing trend in long-term antidepressant use was limited to adults who received their care from general medical providers (adjusted OR = 3.86; 95% CI, 2.57-5.80; P < .001).
From 1999 to 2010, there was a marked increase in long-term use of antidepressant medications in the United States, explaining the overall increasing trend in antidepressant use. This trend calls for greater vigilance in prescribing antidepressants for long periods of time.
评估 1999 年至 2010 年期间美国≥18 岁人群长期使用抗抑郁药的趋势及其相关因素。
我们分析了 6 次横断面全国健康和营养调查（N = 35379）数据中抗抑郁药使用时间的趋势及其与长期使用的相关性，该调查为一般人群的代表性调查。
抗抑郁药的总体使用率从 1999-2000 年的 6.5%增加到 2009-2010 年的 10.4%（比值比[OR] = 1.54；95%置信区间[CI]，1.31-1.81；P <.001）。这包括长期使用（≥24 个月；OR = 2.12；95%CI，1.75-2.57；P <.001）的比例从 3.0%增加到 6.9%。在此期间，中短期（6 至 <24 个月；从 1.3%至 1.6%）和短期（<6 个月；从 2.2%至 1.8%）使用抗抑郁药的比例没有明显变化。长期使用抗抑郁药的上升趋势仅限于从一般医疗提供者那里获得治疗的成年人（调整后的 OR = 3.86；95%CI，2.57-5.80；P <.001）。
从 1999 年到 2010 年，美国长期使用抗抑郁药物的情况明显增加，这解释了抗抑郁药物使用总体上升的趋势。这种趋势要求在长期开具抗抑郁药物时更加警惕。
