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成人脊柱侧弯初次融合术后的生存分析。再次手术的预后因素。

Survivorship analysis after primary fusion for adult scoliosis. Prognostic factors for reoperation.

作者信息

Sánchez-Mariscal Felisa, Gomez-Rice Alejandro, Izquierdo Enrique, Pizones Javier, Zúñiga Lorenzo, Álvarez-González Patricia

机构信息

Spinal Unit, Universitary Hospital of Getafe, Carretera de Toledo km 12.500, 28903, Getafe, Madrid, Spain.

Spinal Unit, Universitary Hospital of Getafe, Carretera de Toledo km 12.500, 28903, Getafe, Madrid, Spain.

出版信息

Spine J. 2014 Aug 1;14(8):1629-34. doi: 10.1016/j.spinee.2013.09.050. Epub 2013 Oct 24.

Abstract

BACKGROUND CONTEXT

Adult scoliosis surgery is a challenging procedure with high rate of complications and reoperations. Reoperation rates vary widely. Long-term survival for this surgery still remains unknown, and the prognostic factors for reoperation are not well defined.

PURPOSE

To assess adult scoliosis surgery survival (without the need of reoperation) after primary fusion in adults with mainly frontal deformity and to define prognostic factors for reoperation.

STUDY DESIGN

Survival analysis of a cohort of consecutive adult patients, primarily operated on scoliosis using segmental instrumentation (retrospective cohort study).

PATIENT SAMPLE

Fifty-nine patients older than 21 years at primary surgery (median age, 42 years), who presented idiopathic or degenerative curves with frontal Cobb >40° (median preoperative frontal Cobb 59°), more than four-level fusion, and a 2-year minimum postoperative follow-up (median, 8.5 years; 41% patients had a longer than 10-year follow-up).

OUTCOME MEASURES

Clinical and preoperative radiographic parameters were analyzed preoperatively and evaluated as prognostic factors for reoperation.

METHODS

Survival was estimated using Kaplan-Meier method. Prognostic factors (clinical and radiographic) for reoperation were evaluated. Logistic regression using backward elimination was used for multivariate analysis.

RESULTS

Survival was 89.8% at 1 year, 79.4% at 2 years, 73.4% at 3 years, 64% at 5 years, and 60.9% at 10 years. Overall, 21 patients (35.6%) underwent revision surgery. The most common reasons for reoperation were painful/prominent implants, adjacent-segment degeneration, and infection. American Society of Anesthesiologists Type II patients and double surgical approach were associated with a higher revision rate. Preoperative thoracic kyphosis was significantly higher in reoperated patients.

CONCLUSIONS

The 10-year survival rate of primary scoliosis surgery in adult patients is 61%. Risk factors identified for reoperation included patients with higher morbidity, double surgical approach, and preoperative thoracic hyperkyphosis.

摘要

背景

成人脊柱侧弯手术是一项具有挑战性的手术,并发症和再次手术发生率较高。再次手术率差异很大。该手术的长期生存率仍然未知,且再次手术的预后因素尚不明确。

目的

评估主要为额状面畸形的成人患者初次融合术后成人脊柱侧弯手术的生存率(无需再次手术),并确定再次手术的预后因素。

研究设计

对一组连续的成年患者进行生存分析,这些患者主要接受了脊柱侧弯节段性内固定手术(回顾性队列研究)。

患者样本

59例初次手术时年龄超过21岁(中位年龄42岁)的患者,表现为特发性或退变性侧弯,额状面Cobb角>40°(术前额状面Cobb角中位数为59°),融合节段超过4个,术后随访至少2年(中位随访时间8.5年;41%的患者随访时间超过10年)。

观察指标

术前分析临床和影像学参数,并将其评估为再次手术的预后因素。

方法

采用Kaplan-Meier法估计生存率。评估再次手术的预后因素(临床和影像学)。使用向后逐步回归的逻辑回归进行多变量分析。

结果

1年生存率为89.8%,2年生存率为79.4%,3年生存率为73.4%,5年生存率为64%,10年生存率为60.9%。总体而言,21例患者(35.6%)接受了翻修手术。再次手术最常见的原因是植入物疼痛/突出、相邻节段退变和感染。美国麻醉医师协会II级患者和双手术入路与较高的翻修率相关。再次手术患者术前胸椎后凸明显更高。

结论

成年患者初次脊柱侧弯手术的10年生存率为61%。确定的再次手术风险因素包括发病率较高的患者、双手术入路和术前胸椎过度后凸。

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