*Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia †Merck Sharp & Dohme, Philadelphia, PA.
J Pediatr Gastroenterol Nutr. 2014 Mar;58(3):278-82. doi: 10.1097/MPG.0000000000000258.
Children with hepatitis C virus infection often differ from adults regarding the rate of viral clearance, duration of infection, and the progression to cirrhosis. In the pediatric population, vertical transmission of hepatitis C virus infection from mother to infant is the most common route of infection. In the present review, we explore the factors that may influence the natural history of hepatitis C virus infection in children who acquire the infection through maternal-fetal transmission. There is particular focus on how viral diversity and the infant immune system may affect viral transmission. An enhanced understanding of maternal-fetal transmission of hepatitis C virus infection has the potential to affect effective drug and vaccine development for both children and adults.
儿童丙型肝炎病毒感染在病毒清除率、感染持续时间和肝硬化进展方面与成人不同。在儿科人群中，丙型肝炎病毒母婴垂直传播是最常见的感染途径。在本综述中，我们探讨了可能影响通过母婴传播感染丙型肝炎病毒的儿童自然史的因素。特别关注病毒多样性和婴儿免疫系统如何影响病毒传播。对丙型肝炎病毒母婴传播的深入了解有可能影响针对儿童和成人的有效药物和疫苗的开发。
