Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM+CSIC, Madrid, Spain.
Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM+CSIC, Madrid, Spain.
Prostaglandins Leukot Essent Fatty Acids. 2014 Jan;90(1):1-4. doi: 10.1016/j.plefa.2013.11.002. Epub 2013 Dec 3.
Several lines of investigation are being developed to assess the impact of polyunsaturated fatty acids, namely those of the omega 3 series, intake on oxidative stress. Keeping in mind that there might be a dose-response relation, in vivo and in vitro data strongly suggest that omega 3 fatty acids might act as anti- rather than pro-oxidant in several cells such as vascular cells, hence diminishing inflammation, oxidative stress, and, in turn, the risk of atherosclerosis and degenerative disorders such as cardiovascular disease.
目前正在开展几条研究途径以评估多不饱和脂肪酸（尤其是ω-3 系列）摄入对氧化应激的影响。鉴于可能存在剂量反应关系，体内和体外数据强烈表明，ω-3 脂肪酸可能在多种细胞（如血管细胞）中表现为抗氧化剂而非促氧化剂，从而减少炎症、氧化应激，进而降低动脉粥样硬化和心血管疾病等退行性疾病的风险。
