体外受精周期反复失败后，等量囊胚与卵裂期胚胎移植的比较。
Comparison of the transfer of equal numbers of blastocysts versus cleavage-stage embryos after repeated failure of in vitro fertilization cycles.
作者信息
Karacan Meric, Ulug Murat, Arvas Ayse, Cebi Ziya, Berberoglugil Munip, Batukan Melike, Camlıbel Teksen
机构信息
Division of Obstetrics and Gynecology, IVF Unit, Ota-Jinemed Hospital, Besiktas, İstanbul, Turkey,
出版信息
J Assist Reprod Genet. 2014 Mar;31(3):269-74. doi: 10.1007/s10815-013-0146-3. Epub 2013 Dec 19.
PURPOSE
To evaluate the efficacy of blastocyst transfer in women with at least two previously unsuccessful in vitro fertilization-embryo transfer (IVF-ET) attempts.
METHODS
Retrospective analysis of 238 couples (with previous implantation failures) had equal number (two) of cleavage-stage embryos (n = 143) or blastocysts (n = 95) transferred in the same IVF center.
RESULTS
The clinical pregnancy rates and live-birth rates were similar in the cleavage-stage embryo transfer group and the blastocyst group (35.6% vs. 40% and 32.1% vs. 35.7%; p > 0.05, respectively). Miscarriage rates (9.8% vs. 10.5%) and multiple pregnancy rates (15.6% vs. 23.6%) did not differ. Although implantation rate was higher with blastocyst transfer than that with day 3 transfer, it did not reach to a statistical significance (24.7% and 19%, respectively, p > 0.05).
CONCLUSION
Blastocyst transfer in ICSI cycles does not yield a better outcome than that obtained with cleavage-stage embryos in women who had unsuccessful IVF attempts previously.
目的
评估囊胚移植对既往至少两次体外受精-胚胎移植（IVF-ET）失败女性的疗效。
方法
对238对夫妇（既往有植入失败史）进行回顾性分析，这些夫妇在同一IVF中心移植了数量相等（两个）的卵裂期胚胎（n = 143）或囊胚（n = 95）。
结果
卵裂期胚胎移植组和囊胚组的临床妊娠率和活产率相似（分别为35.6%对40%和32.1%对35.7%；p>0.05）。流产率（9.8%对10.5%）和多胎妊娠率（15.6%对23.6%）无差异。虽然囊胚移植的植入率高于第3天移植，但未达到统计学显著性（分别为24.7%和19%，p>0.05）。
结论
在既往IVF失败的女性中，ICSI周期中的囊胚移植并不比卵裂期胚胎移植产生更好的结果。
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