Allahveisi Azra, Seyedoshohadaei Fariba, Rezaei Masomeh, Bazrafshan Narges, Rahimi Kaveh
Infertility Treatment Center of Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Department of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Heliyon. 2020 Mar 12;6(3):e03577. doi: 10.1016/j.heliyon.2020.e03577. eCollection 2020 Mar.
The aim of this study was to evaluate the effect of platelet-rich plasma (PRP) on the rate of implantation and pregnancy in women with repeated failed implantation during frozen embryo transfer.
This study was conducted on 50 infertile women candidates (who were referred to the Infertility Treatment Center of Besat Hospital in Sanandaj) with a history of failed implantation for the purpose of frozen embryo transfer. The participants were randomly divided into two groups (n = 25). In the first group (control), the intrauterine infusion of 0.5 ml of Ringer serum was done 48 h before embryo transfer. In the second group (treatment), the intrauterine infusion of 0.5 ml of PRP was performed 48 h before embryo transfer.
In this study, there was no significant difference between the two groups in the rate of chemical and clinical pregnancy. The rate of chemical pregnancy was 28% in the treatment group and 36% in the control group, while the rate of clinical pregnancy was 28% in the treatment group and 24% in the control group.
The intrauterine infusion of PRP before frozen embryo transfer in infertile women with a history of failed implantation will not make any significant effect on the result of pregnancy.
本研究旨在评估富血小板血浆（PRP）对冷冻胚胎移植期间反复种植失败女性的着床率和妊娠率的影响。
本研究针对50名有冷冻胚胎移植种植失败史的不孕女性候选人（转诊至萨南达杰贝萨特医院不孕治疗中心）开展。参与者被随机分为两组（n = 25）。第一组（对照组）在胚胎移植前48小时进行0.5毫升林格氏液的宫腔灌注。第二组（治疗组）在胚胎移植前48小时进行0.5毫升PRP的宫腔灌注。
在本研究中，两组在生化妊娠率和临床妊娠率方面无显著差异。治疗组的生化妊娠率为28%，对照组为36%，而治疗组的临床妊娠率为28%，对照组为24%。
对于有种植失败史的不孕女性，在冷冻胚胎移植前进行PRP宫腔灌注对妊娠结果无显著影响。
