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弥漫性神经纤维瘤——脱发的罕见病因。

Diffuse neurofibroma--an uncommon cause of alopecia.

作者信息

Macias Vasco Coelho, Rafael Margarida, Fernandes Cândida, Rosa Joaninha Costa

机构信息

Hospital de Curry Cabral, Department of Dermatology and Venereology, Lisbon, Portugal.

Instituto Português de Oncologia Francisco Gentil, Department of Dermatology, Lisbon, Portugal.

出版信息

An Bras Dermatol. 2013 Nov-Dec;88(6 Suppl 1):166-9. doi: 10.1590/abd1806-4841.20132170.

Abstract

Although infrequent, alopecia can be caused by benign cutaneous tumours. Neurofibromas are common benign tumors that originate in the peripheral nerve sheath. Diffuse neurofibroma is a rare variant of neurofibroma that is thought to occur mainly in the head and neck of children and young adults. Histology generally shows an infiltrative tumor, composed of spindle cells in the dermis and subcutaneous tissue. Despite being rare, malignant transformation has been reported. The association between diffuse neurofibromas and neurofibromatosis type 1 still remains to be determined since some authors question the low incidence usually described. We report the case of a 42-year-old man who had a diffuse neurofibroma on the scalp presenting as alopecic plaques.

摘要

尽管并不常见,但脱发可能由良性皮肤肿瘤引起。神经纤维瘤是起源于周围神经鞘的常见良性肿瘤。弥漫性神经纤维瘤是神经纤维瘤的一种罕见变体,被认为主要发生在儿童和年轻人的头颈部。组织学检查通常显示为浸润性肿瘤,由真皮和皮下组织中的梭形细胞组成。尽管罕见,但已有恶性转化的报道。由于一些作者对通常所描述的低发病率提出质疑,弥漫性神经纤维瘤与1型神经纤维瘤病之间的关联仍有待确定。我们报告了一例42岁男性患者,其头皮上有弥漫性神经纤维瘤,表现为脱发斑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68b7/3876007/17b7994e3689/abd-88-06-s1-0166-g01.jpg

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