利用镧系元素结合标签和 NMR 赝接触位移打破多天线复合 N-聚糖的伪对称性。
Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts.
机构信息
Departamento de Química Orgánica I, Fac. C. C. Químicas, Universidad Complutense de Madrid, 28040 Madrid (Spain).
出版信息
Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13789-93. doi: 10.1002/anie.201307845. Epub 2013 Nov 4.
PMID:24346952
Abstract
Controlling NMR shifts by lanthanides tagged to a "symmetrical" N-glycan reveals individual resonances for the residues of the otherwise identical A and B arms. This method provides a global perspective of conformational features and interactions in solution.
摘要
通过将镧系元素标记到“对称”N-聚糖上来控制 NMR 位移，揭示了 otherwise identical A 和 B 臂的残基的各个共振峰。该方法提供了溶液中构象特征和相互作用的全局视角。
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