Sengupta Pallav, Banerjee Rajdeb
Department of Physiology, Vidyasagar College for Women, University of Calcutta, Kolkata, West Bengal, India
Department of Physiology, University of Calcutta, Kolkata, West Bengal, India.
Hum Exp Toxicol. 2014 Oct;33(10):1017-39. doi: 10.1177/0960327113515504. Epub 2013 Dec 17.
This review comprehensively summarizes the effects of more than 15 mostly used pesticides on male reproductive physiology, as recent experimental and epidemiological research have indicated their alarming impact on overall human health. Mechanisms have described that pesticide exposure damages spermatozoa, alter Sertoli or Leydig cell function, both in vitro and in vivo and thus affects semen quality. But, the literature suggests a need for more intricate research in those pesticides that are defined as mutagens or carcinogens and directly affect the hypothalamic-pituitary-gonadal axis. This literature review also proposes specific solutions to overcome these health effects.
本综述全面总结了15种以上最常用农药对男性生殖生理的影响，因为最近的实验和流行病学研究表明它们对人类整体健康具有惊人的影响。已有机制描述了农药暴露在体外和体内都会损害精子、改变支持细胞或睾丸间质细胞的功能，从而影响精液质量。但是，文献表明需要对那些被定义为诱变剂或致癌物且直接影响下丘脑-垂体-性腺轴的农药进行更深入的研究。本综述还提出了克服这些健康影响的具体解决方案。
