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Roux-en-Y 胃旁路术后吻合口溃疡的管理:一项国际调查结果。

Management of anastomotic ulcers after Roux-en-Y gastric bypass: results of an international survey.

机构信息

Department of Visceral and Transplantation Surgery, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland,

出版信息

Obes Surg. 2014 May;24(5):741-6. doi: 10.1007/s11695-013-1152-3.

Abstract

BACKGROUND

Anastomotic ulcers (AUs) after Roux-en-Y gastric bypass (RYGB) occur in up to 16% of patients. In an international survey among members of the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO), current preventative and therapeutic strategies in AU were analyzed.

METHODS

An Internet-based survey was performed.

RESULTS

One hundred eighty-nine surgeons completed the survey. Preoperative screening for Helicobacter pylori is performed by 65%. Eighty-eight percent of them prophylactically prescribe antacids for 3 months after surgery (interquartile range (IQR) 1-6). In case of AU, 99% of participants opt for proton pump inhibitors (PPIs) either alone (60%) or in combination with sucralfate (39%). After ulcer resolution, 52% continue PPI for 6 (3-6) months. In case of AU recurrence, 56% continue with conservative treatment. In contrast, 41% of them favor a renewal of the gastrojejunal anastomosis either combined with truncal vagotomy (18%) or with gastric remnant resection (13%), and only 2% choose to resect both gastric pouch and gastric remnant with subsequent reconstruction by esophagojejunostomy. In case of recurrence after surgical revision, 46% of participants opt again for a conservative approach, while 36% chose to redo the gastrojejunostomy once again.

CONCLUSIONS

The majority of bariatric surgeons recommend preoperative screening and eradication of H. pylori as well as prophylactic use of PPI. If an AU is diagnosed, the role of PPI as a first-line treatment seems to be undisputed. However, dosage and duration of therapy remain unclear. In refractory AU, there is no consensus among bariatric surgeons whether conservative treatment or surgical revision should be performed.

摘要

背景

Roux-en-Y 胃旁路术(RYGB)后吻合口溃疡(AU)的发生率高达 16%。在国际肥胖与代谢外科学会联合会(IFSO)成员的国际调查中,分析了 AU 的当前预防和治疗策略。

方法

进行了基于互联网的调查。

结果

189 名外科医生完成了调查。65%的外科医生对幽门螺杆菌进行术前筛查。他们中有 88%预防性地在手术后开具抗酸剂 3 个月(四分位距(IQR)1-6)。对于 AU,99%的参与者选择单独使用质子泵抑制剂(PPIs)(60%)或与硫糖铝联合使用(39%)。在 AU 愈合后,52%的人继续使用 PPI 6(3-6)个月。对于 AU 复发,56%的人继续采用保守治疗。相比之下,41%的人倾向于再次进行胃空肠吻合术,要么联合迷走神经切断术(18%),要么联合胃残端切除术(13%),只有 2%的人选择切除胃袋和胃残端,随后通过食管空肠吻合术重建。在手术修正后复发的情况下,46%的参与者再次选择保守方法,而 36%的人选择再次进行胃空肠吻合术。

结论

大多数减肥外科医生建议进行术前筛查和根除 H. pylori,并预防性使用 PPI。如果诊断出 AU,PPI 作为一线治疗方法似乎是无可争议的。然而,剂量和治疗持续时间仍不清楚。在难治性 AU 中,减肥外科医生之间没有共识,是采用保守治疗还是手术修正。

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