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地佐辛预防丙泊酚注射痛：与利多卡因的比较。

Prevention of injection pain due to propofol by dezocine: a comparison with lidocaine.

作者信息

Lu Yao, Ye Zhang, Wong Gordon Tin Chun, Dong Chunshan, Yu Junma

机构信息

Department of Anesthesiology, Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China ; Department of Anesthesiology, Third Affiliated Hospital of Anhui Medical University, Hefei 230601, China.

Department of Anesthesiology, Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.

出版信息

Indian J Pharmacol. 2013 Nov-Dec;45(6):619-21. doi: 10.4103/0253-7613.121376.

DOI:10.4103/0253-7613.121376
PMID:24347773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3847255/
Abstract

OBJECTIVES

The aim of this study was to investigate the efficacy of dezocine (DEZ) versus placebo control (CON) and 2% lidocaine (LID) in prevention of injection pain due to DEZ.

MATERIALS AND METHODS

A prospective randomized double-blind, placebo-CON study was conducted in 75 adults, American Society of Anesthesiologists physical status I or II, scheduled to undergo an elective surgery. A total of 25 patients were randomly assigned to one of the three groups, thus CON, group LID and group DEZ. The groups received either 2 ml of normal saline or 2 ml 2% LID or 2 mg/2 ml DEZ, respectively, as pre-treatment. Propofol was injected 1 min later. A blinded researcher assessed the patient's pain level using a four point verbal rating scale.

RESULTS

Less patients experienced pain due to propofol injection in the LID (40%) and DEZ (28%) groups compared with the CON (84%) group (P < 0.05). Six patients (24%) in the CON group reported severe pain during propofol injection but none in the other two groups.

CONCLUSION

Pre-treatment with DEZ decreases propofol injection pain as effectively as LID.

摘要

目的

本研究旨在探讨地佐辛（DEZ）与安慰剂对照（CON）以及2%利多卡因（LID）预防因地佐辛引起的注射疼痛的疗效。

材料与方法

对75例计划接受择期手术、美国麻醉医师协会身体状况为I或II级的成年人进行了一项前瞻性随机双盲、安慰剂对照研究。总共25例患者被随机分配到三组之一，即CON组、LID组和DEZ组。三组分别接受2 ml生理盐水或2 ml 2%利多卡因或2 mg/2 ml地佐辛作为预处理。1分钟后注射丙泊酚。一名盲法研究人员使用四点语言评定量表评估患者的疼痛程度。

结果

与CON组（84%）相比，LID组（40%）和DEZ组（28%）中因丙泊酚注射而经历疼痛的患者较少（P < 0.05）。CON组中有6例患者（24%）在丙泊酚注射期间报告有严重疼痛，而其他两组均无。

结论

地佐辛预处理在减轻丙泊酚注射疼痛方面与利多卡因同样有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eef/3847255/59cad8ba04c4/IJPharm-45-619-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eef/3847255/59cad8ba04c4/IJPharm-45-619-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8eef/3847255/59cad8ba04c4/IJPharm-45-619-g001.jpg

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