Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.
Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003; Department of Anesthesiology, Changxing Hospital of Traditional Chinese Medicine, Changxing County, Huzhou, Zhejiang 313100, China.
Chin Med J (Engl). 2018 Aug 20;131(16):1958-1963. doi: 10.4103/0366-6999.238138.
Intravenous (IV) oxycodone has been used at induction to prevent an intubation reaction. The aims of the current study were to calculate the median effective dose (ED) and the 95% effective dose (ED) of an IV bolus of oxycodone that blunts the hemodynamic response to tracheal intubation with propofol according to gender and to observe the adverse events of induction-dose oxycodone.
Adult patients who required general anesthesia and tracheal intubation were enrolled. Tracheal intubation was performed using unified TD-C-IV video laryngoscopy and an ordinary common endotracheal tube. Dixon's up-and-down method was used to obtain EDdata for women and men separately. The initial dose of oxycodone was 0.2 mg/kg for women and 0.3 mg/kg for men (step size was 0.01 mg/kg). Next, a dose-response curve from the probit analysis was generated to determine the EDand EDto blunt the intubation reaction in female and male patients. Adverse events following oxycodone injection were observed for 5 min before propofol injection.
Sixty-three patients were analyzed, including 29 females and 34 males. According to the probit analysis, the ED and EDof oxycodone required to blunt the intubation reaction in women were 0.254 mg/kg (95% confidence interval [CI], 0.220-0.328 mg/kg) and 0.357 mg/kg (95% CI, 0.297-2.563 mg/kg), respectively. In men, the ED and EDwere 0.324 mg/kg (95% CI, 0.274-0.381 mg/kg) and 0.454 mg/kg (95% CI, 0.384-2.862 mg/kg), respectively. Men required 28% more oxycodone than women for induction (P < 0.01). The most common adverse events were dizziness (87.3%), vertigo (66.7%), sedation (74.6%), and respiratory depression (66.7%).
Oxycodone can be used for induction to prevent intubation reactions. Gender affected the EDand EDof oxycodone for blunting the tracheal intubation reaction.
静脉注射（IV）羟考酮已被用于诱导以防止插管反应。本研究的目的是计算静脉推注羟考酮的中位有效剂量（ED）和 95%有效剂量（ED），以根据性别减轻异丙酚诱导气管插管的血流动力学反应，并观察诱导剂量羟考酮的不良事件。
纳入需要全身麻醉和气管插管的成年患者。气管插管采用统一的 TD-C-IV 视频喉镜和普通普通气管内管进行。采用 Dixon 的上下法分别获得女性和男性的 ED 数据。女性羟考酮的初始剂量为 0.2mg/kg，男性为 0.3mg/kg（步长为 0.01mg/kg）。然后，从概率分析生成剂量-反应曲线，以确定 ED 和 ED 以减轻女性和男性患者的插管反应。在注射异丙酚前观察 5 分钟内注射羟考酮后的不良事件。
共分析了 63 例患者，其中女性 29 例，男性 34 例。根据概率分析，女性需要 0.254mg/kg（95%置信区间[CI]，0.220-0.328mg/kg）和 0.357mg/kg（95%CI，0.297-2.563mg/kg）来减轻插管反应的羟考酮 ED 和 ED。在男性中，ED 和 ED 分别为 0.324mg/kg（95%CI，0.274-0.381mg/kg）和 0.454mg/kg（95%CI，0.384-2.862mg/kg）。男性诱导所需的羟考酮比女性多 28%（P<0.01）。最常见的不良事件是头晕（87.3%）、眩晕（66.7%）、镇静（74.6%）和呼吸抑制（66.7%）。
羟考酮可用于诱导以防止插管反应。性别影响羟考酮减轻气管插管反应的 ED 和 ED。
