Lanier Ryan K, Cohen Amy E, Weinkle Susan H
Rock Creek Pharmaceuticals, Inc., Gloucester, Mass., USA.
Private practice, Bradenton, Fla., USA.
Case Rep Dermatol. 2013 Nov 23;5(3):347-56. doi: 10.1159/000357019. eCollection 2013.
Current medical and scientific research indicates that rosacea, a chronic and often debilitating skin condition that primarily affects the central face, may be caused by an overactive or excessive inflammatory immune response. Regardless of etiology, the accompanying redness and inflammation is unsightly and difficult for the patient. Anatabine is an alkaloid from the plant family Solanaceae that has been shown in several preclinical studies to modulate proinflammatory signaling pathways.
A cream containing anatabine was developed and evaluated in an open-label case series study for safety and effects on the appearance of the skin in 10 patients with mild to moderate rosacea.
Patients applied the cream to the face twice daily for a period of 30 days. Patients and the study physician completed safety and efficacy assessments at study end.
Results showed that 50% of the patients self-reported improvement in the appearance of their skin, and the physician noted improvement in 70% of the patients. Photographs taken before and after 30 days of cream use provide visual evidence of the improvement in several patients. There were no complications or adverse events reported by any of the patients in the study, indicating that the anatabine cream was safe and very well tolerated.
The results of this open-label case series show that a facial cream containing anatabine can improve the appearance of the skin in patients with mild to moderate rosacea and suggest that a double-blind, vehicle-controlled trial in a larger number of subjects is warranted.
当前的医学和科学研究表明，酒渣鼻是一种主要影响面部中央的慢性且常使人衰弱的皮肤疾病，可能由过度活跃或过度的炎症免疫反应引起。无论病因如何，伴随的发红和炎症都很难看且给患者带来困扰。去甲替林是一种来自茄科植物的生物碱，在多项临床前研究中已显示其可调节促炎信号通路。
开发了一种含去甲替林的乳膏，并在一项开放标签病例系列研究中对10例轻至中度酒渣鼻患者的安全性及对皮肤外观的影响进行了评估。
患者每天两次将乳膏涂抹于面部，持续30天。患者和研究医生在研究结束时完成安全性和疗效评估。
结果显示，50%的患者自我报告皮肤外观有改善，医生指出70%的患者有改善。使用乳膏30天前后拍摄的照片为几名患者的改善情况提供了视觉证据。该研究中没有患者报告有并发症或不良事件，表明去甲替林乳膏安全且耐受性良好。
该开放标签病例系列的结果表明，含去甲替林的面霜可改善轻至中度酒渣鼻患者的皮肤外观，并表明有必要在更多受试者中进行双盲、赋形剂对照试验。
