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TU-100 对小鼠 2 型结肠炎模型的预防作用：可能涉及增强肠上皮细胞中的肾上腺髓质素。

Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells.

机构信息

Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan.

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan ; Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo 065-0033, Japan.

出版信息

Gastroenterol Res Pract. 2013;2013:384057. doi: 10.1155/2013/384057. Epub 2013 Nov 19.

DOI:10.1155/2013/384057
PMID:24348533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3852085/
Abstract

Purpose. Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel disease (IBD), have histopathologically and immunologically different characteristics. We previously reported that a traditional Japanese medicine, daikenchuto (TU-100), ameliorated a trinitrobenzenesulfonic acid- (TNBS-) induced type-1 model colitis exhibiting histopathological features of CD through adrenomedullin (ADM) enhancement. Our current aims were to examine whether TU-100 ameliorates a type-2 model colitis that histologically resembles UC and identify the active ingredients. Methods. TU-100 was administered orally to mice with oxazolone- (OXN-) induced type-2 model colitis. The morbidity was evaluated by body weight loss and the macroscopic score of colonic lesions. ADM was quantified using an EIA kit. Results. TU-100 prevented weight loss and colon ulceration. ADM production by intestinal epithelial cells was increased by TU-100 addition. Screening to identify active ingredients showed that [6]-shogaol and hydroxy α -sanshool enhanced ADM production. Conclusions. TU-100 exerted a protective effect in OXN-induced type-2 model colitis, indicating that TU-100 may be a beneficial agent for treatment of UC.

摘要

目的。克罗恩病（CD）和溃疡性结肠炎（UC）是两种主要的炎症性肠病（IBD），它们在组织病理学和免疫学上具有不同的特征。我们之前曾报道，一种传统的日本药物，大建中汤（TU-100）通过增强肾上腺髓质素（ADM），改善了一种表现出 CD 组织病理学特征的三硝基苯磺酸（TNBS）诱导的 1 型模型结肠炎。我们目前的目的是研究 TU-100 是否能改善类似于 UC 的组织学特征的 2 型模型结肠炎，并确定其有效成分。方法。将 TU-100 口服给予氧化偶氮甲烷（OXN）诱导的 2 型模型结肠炎小鼠。通过体重减轻和结肠病变的宏观评分来评估发病率。使用 EIA 试剂盒定量 ADM。结果。TU-100 可预防体重减轻和结肠溃疡。TU-100 的添加可增加肠上皮细胞 ADM 的产生。活性成分的筛选表明，[6]-姜烯和羟基 α -山椒素增强了 ADM 的产生。结论。TU-100 在 OXN 诱导的 2 型模型结肠炎中发挥了保护作用，表明 TU-100 可能是治疗 UC 的有益药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/3852085/d3adc5713920/GRP2013-384057.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/3852085/7b0e3d21ddf1/GRP2013-384057.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/3852085/d3adc5713920/GRP2013-384057.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/3852085/7b0e3d21ddf1/GRP2013-384057.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea3/3852085/d3adc5713920/GRP2013-384057.002.jpg

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Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy.白细胞介素-2 在效应反应、耐受和免疫治疗的十字路口。
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Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine.
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Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100).食用大建中汤（TU - 100）对肠道微生物群的时间、性别和剂量依赖性改变。
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