Azizi Fereidoun, Mirmiran Parvin, Momenan Amir Abbas, Hadaegh Farzad, Habibi Moeini Ali, Hosseini Firoozeh, Zahediasl Saleh, Ghanbarian Arash, Hosseinpanah Farhad
Endocrine, Obesity and Prevention of Metabolic Disease Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Int J Endocrinol Metab. 2013 Summer;11(3):145-53. doi: 10.5812/ijem.5443. Epub 2013 Jul 1.
It has been shown that life style modification may decrease the prevalence of metabolic syndrome, but this intervention has not been reported in community setting.
Effect of lifestyle modification on prevalence of metabolic syndrome and its components were assessed in an urban population.
In 6870 participants of Tehran Lipid and Glucose Study aged 20-74 years, the prevalence of metabolic syndrome and its components were measured before and after a 3.6 years interval. Lifestyle intervention was employed at a community level including 2961 individuals and also 3909 subjects which were recruited as controls. Logistic regression analysis was adjusted for age, sex and medications.
After 3.6 years, the rise in the prevalence of metabolic syndrome was less prominent in intervention than control group (P < 0.002 for increase of metabolic syndrome prevalence between groups), with an OR of 0.84 (confidence interval 0.75-0.95). After intervention the prevalence of abdominal obesity, elevated fasting glucose levels, elevated triglyceride and low HDL cholesterol were more prominent in control group, as compared to intervention group.
Community based lifestyle modifications in Tehranian adults delayed rise in the prevalence of metabolic syndrome and some of its components.
研究表明，生活方式的改变可能会降低代谢综合征的患病率，但在社区环境中尚未有此类干预措施的报道。
评估城市人群中生活方式改变对代谢综合征及其各组分患病率的影响。
在德黑兰血脂与血糖研究的6870名年龄在20 - 74岁的参与者中，间隔3.6年前后测量代谢综合征及其各组分的患病率。在社区层面进行生活方式干预，干预组包括2961人，同时招募3909名受试者作为对照组。逻辑回归分析对年龄、性别和药物进行了校正。
3.6年后，干预组代谢综合征患病率的上升幅度低于对照组（两组间代谢综合征患病率增加的P < 0.002），比值比为0.84（置信区间0.75 - 0.95）。干预后，与干预组相比，对照组腹部肥胖、空腹血糖水平升高、甘油三酯升高和高密度脂蛋白胆固醇降低的患病率更为显著。
在德黑兰成年人中基于社区的生活方式改变延缓了代谢综合征及其部分组分患病率的上升。
