Song Wei, Zhang Kai, Sun Jinhua, Ma Lina, Jesse Forrest Fabian, Teng Xiaochun, Zhou Ying, Bao Hechen, Chen Shiqing, Wang Shuai, Yang Beimeng, Chu Xixia, Ding Wenhua, Du Yasong, Cheng Zaohuo, Wu Bin, Chen Shanguang, He Guang, He Lin, Chen Xiaoping, Li Weidong
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.
Wuxi Mental Health Center, Wuxi 214151, China.
Neural Plast. 2013;2013:130642. doi: 10.1155/2013/130642. Epub 2013 Nov 20.
People with neuropsychiatric disorders such as schizophrenia often display deficits in spatial working memory and attention. Evaluating working memory and attention in schizophrenia patients is usually based on traditional tasks and the interviewer's judgment. We developed a simple Spatial Working Memory and Attention Test on Paired Symbols (SWAPS). It takes only several minutes to complete, comprising 101 trials for each subject. In this study, we tested 72 schizophrenia patients and 188 healthy volunteers in China. In a healthy control group with ages ranging from 12 to 60, the efficiency score (accuracy divided by reaction time) reached a peak in the 20-27 age range and then declined with increasing age. Importantly, schizophrenia patients failed to display this developmental trend in the same age range and adults had significant deficits compared to the control group. Our data suggests that this simple Spatial Working Memory and Attention Test on Paired Symbols can be a useful tool for studies of spatial working memory and attention in neuropsychiatric disorders.
患有精神分裂症等神经精神疾病的人通常在空间工作记忆和注意力方面存在缺陷。评估精神分裂症患者的工作记忆和注意力通常基于传统任务和面试官的判断。我们开发了一种简单的配对符号空间工作记忆和注意力测试（SWAPS）。完成该测试仅需几分钟，每个受试者有101次试验。在本研究中，我们在中国测试了72名精神分裂症患者和188名健康志愿者。在年龄范围为12至60岁的健康对照组中，效率得分（准确率除以反应时间）在20 - 27岁年龄范围内达到峰值，然后随着年龄增长而下降。重要的是，精神分裂症患者在同一年龄范围内未表现出这种发育趋势，并且与对照组相比，成年人存在明显缺陷。我们的数据表明，这种简单的配对符号空间工作记忆和注意力测试可以成为研究神经精神疾病中空间工作记忆和注意力的有用工具。
