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神经科学、儿童公共卫生与教育实践的整合:特定大脑半球矫正策略作为 ADD/ADHD 相关联康复工具的一门学科。

The Integration of the Neurosciences, Child Public Health, and Education Practice: Hemisphere-Specific Remediation Strategies as a Discipline Partnered Rehabilitation Tool in ADD/ADHD.

机构信息

The National Institute for Brain and Rehabilitation Sciences , Nazareth , Israel ; Human Factors, Department of Biomechanics, ORT-Braude College of Engineering , Karmiel , Israel ; Neurology, University of the Medical Sciences , Havana , Cuba.

The National Institute for Brain and Rehabilitation Sciences , Nazareth , Israel ; Nazareth Academic Institute , Nazareth , Israel ; Oranim Academic College of Education , Qiriat Tivon , Israel.

出版信息

Front Public Health. 2013 Jul 25;1:22. doi: 10.3389/fpubh.2013.00022. eCollection 2013.

Abstract

ADD/ADHD is the most common and most studied neurodevelopmental problem. Recent statistics from the U.S. Center for Disease Control state that 11% or approximately one out of every nine children in the US and one in five high school boys are diagnosed with ADD/ADHD. This number is thought to be increasing at around 15-20% per year. The US National Institute of Mental Health's Multi-modal Treatment Study has shown that medication has no long-term benefit for those with ADHD. To effectively address ADD/ADHD from within the framework of child public health, an interdisciplinary strategy is necessary that is based on a neuroeducational model that can be readily implemented on a large-scale within the educational system. This study is based on previous findings that ADD/ADHD children possess underactivity between sub-cortical and cortical regions. An imbalance of activity or arousal in one area can result in functional disconnections similar to that seen in split-brain patients. Since ADD/ADHD children exhibit deficient performance on tests developed to measure perceptual laterality, evidence of weak laterality or failure to develop laterality has been found across various modalities (auditory, visual, tactile). This has reportedly resulted in abnormal cerebral organization and ineffective cortical specialization necessary for the development of language and non-language function. This pilot study examines groups of ADD/ADHD and control elementary school children all of whom were administered all of the subtests of the Wechsler Individual Achievement Tests, the Brown Parent Questionnaire, and given objective performance measures on tests of motor and sensory coordinative abilities. Results measured after a 12-week remediation program aimed at increasing the activity of the hypothesized underactive right hemisphere function, yielded significant improvement of greater than 2 years in grade level in all domains except in mathematical reasoning. The treated group also displayed a significant improvement in behavior with a reduction in Brown scale behavioral scores. Non-treated control participants did not exhibit significant differences during the same 12 week period in academic measurements. Controls were significantly different from treatment participants in all domains after a 12-week period. The non-treatment group also demonstrated an increase in behavioral scores and increased symptoms of ADD/ADHD over the same time period when compared to the treated group. Results are discussed in the context of the concept of functional disconnectivity in ADD/ADHD children.

摘要

注意力缺陷多动障碍(ADHD)是最常见和研究最多的神经发育问题。美国疾病控制中心最近的统计数据显示,美国大约每 9 个孩子中就有 1 个(即 11%),每 5 个高中男生中就有 1 个被诊断患有 ADHD。据认为,这一数字每年以 15-20%的速度增长。美国国家心理健康研究所的多模式治疗研究表明,药物对 ADHD 患者没有长期益处。为了从儿童公共卫生的框架内有效解决 ADHD,需要一种跨学科的策略,该策略基于神经教育模型,可以在教育系统中大规模实施。本研究基于之前的发现,即 ADHD 儿童在皮质下和皮质区域之间存在活动不足。一个区域的活动或唤醒失衡可能导致类似于裂脑患者的功能连接中断。由于 ADHD 儿童在用于测量感知偏侧性的测试中表现出缺陷,因此在各种模态(听觉、视觉、触觉)中都发现了较弱的偏侧性或未能发展出偏侧性的证据。这据报道导致了大脑组织异常和皮质专门化无效,这对于语言和非语言功能的发展是必要的。这项初步研究检查了 ADHD 和对照组的小学生群体,他们都接受了韦氏个人成就测试的所有子测试、布朗父母问卷,并在运动和感觉协调能力测试中接受了客观的表现测试。在一项为期 12 周的旨在增加假设的活动不足的右半球功能的补救计划后,测量的结果显示,除了数学推理之外,所有领域的年级水平都有超过 2 年的显著提高。治疗组在布朗量表行为评分方面也表现出显著改善。在相同的 12 周期间,对照组在学业测量中没有表现出显著差异。治疗组在 12 周后,在所有领域都与对照组有显著差异。与治疗组相比,非治疗组在同一时期内,行为评分也增加,ADD/ADHD 症状加重。结果在 ADHD 儿童功能连接中断的概念背景下进行了讨论。

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