Koyama T, Lowy M T, Meltzer H Y
Am J Psychiatry. 1987 Mar;144(3):334-7. doi: 10.1176/ajp.144.3.334.
To determine if the enhanced cortisol response to oral administration of the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) that has been reported in unmedicated depressed and manic patients might be related to brain monoaminergic metabolism, the authors assessed correlations between 5-HTP-induced cortisol response and CSF in nine depressed patients. They found a significant negative correlation with CSF levels of 5-hydroxyindoleacetic acid, a 5-HT metabolite, but not with CSF levels of other monoamine metabolites. This finding is consistent with the hypothesis that low presynaptic brain serotonergic activity may be related to enhanced cortisol response to 5-HTP in depressed patients.
为了确定在未接受药物治疗的抑郁和躁狂患者中所报道的，口服血清素（5-羟色胺，5-HT）前体5-羟色氨酸（5-HTP）后增强的皮质醇反应是否可能与脑单胺能代谢有关，作者评估了9名抑郁症患者中5-HTP诱导的皮质醇反应与脑脊液之间的相关性。他们发现，这与5-羟色胺代谢物5-羟吲哚乙酸的脑脊液水平呈显著负相关，但与其他单胺代谢物的脑脊液水平无关。这一发现与以下假设一致，即突触前脑血清素能活性低可能与抑郁症患者对5-HTP的皮质醇反应增强有关。
