从库拉索芦荟凝胶中分离得到的植物甾醇的给药可减少内脏脂肪量并改善 Zucker 糖尿病肥胖（ZDF）大鼠的高血糖症。

Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats.

机构信息

Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate school of Agriculture, Kyoto University, Japan.

出版信息

Obes Res Clin Pract. 2008 Dec;2(4):I-II. doi: 10.1016/j.orcp.2008.06.002.

DOI:10.1016/j.orcp.2008.06.002

PMID:24351850

Abstract

We examined the effects of lophenol (Lo) and cycloartanol (Cy), minor phytosterols of Aloe vera gel, in obese animal model of type II diabetes, Zucker diabetic fatty (ZDF) rats. Male ZDF rats were administered Lo and Cy at 25 μg/(kg day) daily for 44 days. Consecutive treatment of phytosterols suppressed the hyperglycemia, and random blood glucose levels after 35 days of treatment were 39.6 and 37.2% lower than the control, in Lo and Cy treatment groups, respectively. Consistent with the random blood glucose level, hemoglobin A1c (HbA1c) values of phytosterols treated rats were also lower than the control (Lo: 5.5 ± 0.8, Cy: 4.6 ± 0.7 vs. control: 7.2 ± 1.5). In the oral glucose tolerance test (OGTT) after 28 days of administration, the glucose intolerance was improved in phytosterols treatment groups. Additionally, the continuous administration of Lo and Cy also reduced the serum free fatty acid (FFA) and triglyceride (TG) levels except total cholesterol (T-Cho). Furthermore, the weights of total abdominal fat tissues were significantly lower than the control in ZDF rats with Lo (27.7%) and Cy (26.3%) treatment. These observations suggest that Aloe vera-derived phytosterols could reduce visceral fat accumulation, and would be useful for the improvement of hyperlipidemia and hyperglycemia.:

摘要

我们研究了芦酚（Lo）和环阿尔廷醇（Cy）对 2 型糖尿病肥胖动物模型，即 Zucker 糖尿病肥胖（ZDF）大鼠的影响。雄性 ZDF 大鼠每天给予 Lo 和 Cy 25 μg/（kg·天），连续治疗 44 天。连续给予植物甾醇可抑制高血糖，治疗 35 天后，Lo 和 Cy 治疗组的随机血糖水平分别比对照组低 39.6%和 37.2%。与随机血糖水平一致，植物甾醇治疗大鼠的糖化血红蛋白（HbA1c）值也低于对照组（Lo：5.5±0.8，Cy：4.6±0.7 与对照组：7.2±1.5）。在给药 28 天后的口服葡萄糖耐量试验（OGTT）中，植物甾醇治疗组的葡萄糖耐量得到改善。此外，芦酚和环阿尔廷醇的连续给药还降低了血清游离脂肪酸（FFA）和甘油三酯（TG）水平，除总胆固醇（T-Cho）外。此外，Lo（27.7%）和 Cy（26.3%）治疗的 ZDF 大鼠的总腹部脂肪组织重量明显低于对照组。这些观察结果表明，芦荟衍生的植物甾醇可减少内脏脂肪堆积，对改善高血脂和高血糖有一定作用。