Wang Bing-xiang, Zhang Li, Wang Yu-jie, Yan Jun-wei, Wan Ya-nan, Peng Wen-jia, Wang Jing
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Medical Genetics Center, Anhui Medical College, Hefei, China.
Int J STD AIDS. 2014 Jul;25(8):550-8. doi: 10.1177/0956462413515444. Epub 2013 Dec 18.
Illicit drug trade has re-emerged in China since 1979 and the number of drug addicts had increased. Syphilis is mainly spread through sexual contact and blood. The incidence of syphilis is high among drug users. Methadone maintenance treatment (MMT) clinics have been implemented in China since 2004. The aim of this study was to estimate the prevalence and risk factors of syphilis among drug users at MMT clinics in China between 2004 and 2013. Chinese and English databases (CBM, CNKI, Weipu, Pubmed) of literature were searched for studies reporting syphilis among drug users in MMT clinics from 2004 to 2013. The prevalence estimates and risk factors were summarized through a systematic review and meta-analysis of published literatures. In all, 29 eligible articles with a total of 8899 drug users, were selected in this review. The pooled prevalence of syphilis infection was 7.78% (95%CI: 5.83%-9.99%). The meta-analyses demonstrated significant differences in syphilis infection rates between men and women (OR = 0.34 [95%CI: 0.26-0.45]) but not between drug users and non-intravenous drug users (OR = 0.82 [95%CI: 0.51-1.32]). Enhanced detection of syphilis and health promotion is warranted in MMT clinics in China.
自1979年以来，非法毒品交易在中国再度出现，吸毒成瘾者人数不断增加。梅毒主要通过性接触和血液传播。吸毒者中梅毒发病率较高。自2004年起，中国已实施美沙酮维持治疗（MMT）门诊。本研究旨在估算2004年至2013年间中国MMT门诊吸毒者中梅毒的患病率及危险因素。检索中文和英文数据库（中国生物医学文献数据库、中国知网、维普、PubMed），查找2004年至2013年间关于MMT门诊吸毒者梅毒情况的研究报告。通过对已发表文献进行系统综述和荟萃分析，总结患病率估算结果及危险因素。本综述共纳入29篇符合条件的文章，涉及8899名吸毒者。梅毒感染合并患病率为7.78%（95%可信区间：5.83%-9.99%）。荟萃分析表明，梅毒感染率在男性和女性之间存在显著差异（比值比=0.34[95%可信区间：0.26-0.45]），但在吸毒者和非静脉吸毒者之间无显著差异（比值比=0.82[95%可信区间：0.51-1.32]）。中国MMT门诊有必要加强梅毒检测及健康促进工作。
