Obaseiki-Ebor E E, Abiodun P O, Emina P A
Ann Trop Paediatr. 1986 Dec;6(4):283-6. doi: 10.1080/02724936.1986.11748457.
A conjugative R-plasmid PE004, Inc F11, conferring resistance to ampicillin, tetracycline, streptomycin, kanamycin and trimethoprim was obtained from an E. coli serotype 026 isolate from the stool of a child with acute diarrhoea. The R-plasmid PE004 also co-transfers an enteropathogenicity antigen without the production of enterotoxins or manifestation of invasiveness. It is not yet known whether this transferable antigen mediates enterocyte damage with consequent diarrhoea. The R-plasmid was of molecular weight 2.4 megadaltons (3.7 kilobase) with a transfer frequency of 6 x 10(-4) cfu/ml E. coli J53-1. The uncontrolled mediation with antibiotics in cases of acute diarrhoea could select gut bacteria not only possessing R-plasmids conferring resistance to several antibiotics but with associated undesirable extrachromosomal genes.
从一名急性腹泻儿童粪便中分离出的大肠杆菌026血清型菌株中获得了一种接合性R质粒PE004，属于Inc F11，它赋予对氨苄青霉素、四环素、链霉素、卡那霉素和甲氧苄啶的抗性。R质粒PE004还能共转移一种肠致病性抗原，而不产生肠毒素或表现出侵袭性。目前尚不清楚这种可转移抗原是否介导肠细胞损伤并导致腹泻。该R质粒分子量为2.4兆道尔顿（3.7千碱基），在大肠杆菌J53-1中的转移频率为6×10⁻⁴ cfu/ml。在急性腹泻病例中不加控制地使用抗生素进行治疗，可能会选择出不仅携带赋予对多种抗生素抗性的R质粒，还带有相关不良额外染色体基因的肠道细菌。
