星形胶质细胞中HIV-1潜伏的表观遗传调控
Epigenetic regulation of HIV-1 latency in astrocytes.
作者信息
Narasipura Srinivas D, Kim Stephanie, Al-Harthi Lena
机构信息
Department of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, USA.
出版信息
J Virol. 2014 Mar;88(5):3031-8. doi: 10.1128/JVI.03333-13. Epub 2013 Dec 18.
Abstract
HIV infiltrates the brain at early times postinfection and remains latent within astrocytes and macrophages. Because astrocytes are the most abundant cell type in the brain, we evaluated epigenetic regulation of HIV latency in astrocytes. We have shown that class I histone deacetylases (HDACs) and a lysine-specific histone methyltransferase, SU(VAR)3-9, play a significant role in silencing of HIV transcription in astrocytes. Our studies add to a growing body of evidence demonstrating that astrocytes are a reservoir for HIV.
摘要
HIV在感染后的早期就侵入大脑，并潜伏在星形胶质细胞和巨噬细胞内。由于星形胶质细胞是大脑中最丰富的细胞类型，我们评估了星形胶质细胞中HIV潜伏的表观遗传调控。我们已经表明，I类组蛋白去乙酰化酶（HDACs）和赖氨酸特异性组蛋白甲基转移酶SU(VAR)3-9在星形胶质细胞中HIV转录的沉默中起重要作用。我们的研究增加了越来越多的证据，证明星形胶质细胞是HIV的一个储存库。
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