Laboratório de Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Cell Biol Int. 2014 Apr;38(4):526-30. doi: 10.1002/cbin.10228. Epub 2014 Jan 10.
(+)-Catechin is a type of catechin present in large amounts in açaí fruits and cocoa seeds. Besides its antioxidant and anti-inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)-catechin on hepatic stellate cells. (+)-Catechin induced quiescent phenotype in GRX cells, along with an increase in lipid droplets. Proliferator-activated receptor γ mRNA expression was upregulated, whereas type I collagen mRNA expression was downregulated. Pro-inflammatory cytokines were not influenced by (+)-catechin, whereas the levels of interleukin 10 were significantly increased. The data provide evidence that (+)-catechin can reduce hepatic stellate cell activation.
（+）-儿茶素是一种大量存在于巴西莓果实和可可种子中的儿茶素。除了其抗氧化和抗炎活性外，人们对其在肝脏中的作用知之甚少，尤其是在肝纤维化期间。我们在这里报告了（+）-儿茶素对肝星状细胞的影响。（+）-儿茶素诱导 GRX 细胞进入静止表型，并增加脂滴。过氧化物酶体增殖物激活受体 γ mRNA 的表达上调，而 I 型胶原 mRNA 的表达下调。（+）-儿茶素并不影响促炎细胞因子，而白细胞介素 10 的水平则显著增加。这些数据表明（+）-儿茶素可以减少肝星状细胞的激活。
