Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Clin Epidemiol. 2013 Dec 9;5:475-81. doi: 10.2147/CLEP.S53420. eCollection 2013.
The purpose of this study was to determine the prevalence of atrial fibrillation (AF) in the general population and to validate an administrative diagnosis register, ie, the National Patient Register (NPR), and an electrocardiography (ECG) database in estimating disease prevalence.
The study was conducted in a well defined region in northern Sweden (population n=75,945) which consists of one hospital and eleven primary health care centers. Subjects with AF were identified by searching the combined inpatient and outpatient International Classification of Diseases (ICD)-based NPR (ICD-10 code I48) and an ECG database with computer-interpreted AF from January 1, 2004 to December 31, 2010. All identified cases with AF were validated.
AF was confirmed in 2,274 patients. The overall prevalence was 3.0% (3.4% in men and 2.6% in women). AF prevalence rose steadily with age, and was 16.8% in patients aged 75 years and older and 21.9% in patients 85 years and older. Of all patients with validated AF, the NPR identified 93.2%. The ECG database identified an additional 6.8%, of which 81% were over 70 years of age. According to the NPR, the proportion of false positives and false negatives was 3.5% and 6.8%, respectively. The corresponding figure for the ECG database was 11.3% and 9.2%, respectively.
Our study shows a high prevalence of AF, especially among the elderly. Searching the ECG database enhanced the detection of AF. The reliability of the NPR was high, with a relatively low proportion of false positives and negatives.
本研究旨在确定普通人群中心房颤动（AF）的患病率，并验证行政诊断登记处，即国家患者登记处（NPR）和心电图（ECG）数据库，以估计疾病的患病率。
该研究在瑞典北部一个定义明确的地区进行（人口 n=75945），该地区由一家医院和十一家初级保健中心组成。通过搜索基于国际疾病分类（ICD）的综合住院和门诊 NPR（ICD-10 代码 I48）和具有计算机解释的 AF 的 ECG 数据库，从 2004 年 1 月 1 日至 2010 年 12 月 31 日，确定了所有患有 AF 的患者。所有确诊的 AF 病例均经过验证。
共确诊 2274 例 AF。总体患病率为 3.0%（男性为 3.4%，女性为 2.6%）。AF 患病率随年龄稳步上升，在 75 岁及以上患者中为 16.8%，在 85 岁及以上患者中为 21.9%。在所有经验证的 AF 患者中，NPR 确定了 93.2%。ECG 数据库另外确定了 6.8%，其中 81%的患者年龄在 70 岁以上。根据 NPR，假阳性和假阴性的比例分别为 3.5%和 6.8%。ECG 数据库的相应数字分别为 11.3%和 9.2%。
我们的研究显示 AF 的患病率很高，尤其是在老年人中。搜索 ECG 数据库可增强 AF 的检测。NPR 的可靠性很高，假阳性和假阴性的比例相对较低。
