XRCC1 Arg280His 多态性与胶质瘤风险的关联：一项包含 1439 例病例和 2564 例对照的荟萃分析。
XRCC1 Arg280His polymorphism and glioma risk: A meta-analysis involving 1439 cases and 2564 controls.
机构信息
Liang Zhang, Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
Yan Wang, Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
出版信息
Pak J Med Sci. 2013 Jan;29(1):37-42. doi: 10.12669/pjms.291.2694.
OBJECTIVES
Previous reports indicated that XRCC1 Arg280His polymorphism might be a possible risk factor for several cancers. Published studies on the association of XRCC1 Arg280His polymorphisms with glioma risk have yielded controversial results. The present study aimed to derive a more precise estimation of the relationship.
METHODOLOGY
Meta-analyses assessing the association of XRCC1 Arg280His variation with glioma were conducted and subgroup analyses on ethnicity and source of controls were further performed. Eligible studies for the period up to May 2012 were identified.
RESULTS
A total of four case-control studies comprising 1439 cases and 2564 controls were selected for analysis. The overall data indicated no significant association of XRCC1 Arg280His polymorphism with glioma risk (His vs Arg: OR=1.05; 95%CI=0.88-1.25; His/His vs Arg/Arg: OR=1.42; 95%CI=0.87-2.29; dominant model: OR=1.00; 95%CI=0.82-1.22; recessive model: OR=1.41; 95%CI=0.88-2.25). Likewise, in the subgroup analysis regarding ethnicity and source of controls, no associations were observed.
CONCLUSION
The results of the present study failed to suggest an association of XRCC1 Arg280His polymorphism with glioma risk. Further large and well-designed studies are needed to confirm this conclusion.
目的
先前的报告表明，XRCC1 Arg280His 多态性可能是多种癌症的一个潜在危险因素。已发表的关于 XRCC1 Arg280His 多态性与神经胶质瘤风险之间关系的研究结果存在争议。本研究旨在得出更精确的评估结果。
方法
对评估 XRCC1 Arg280His 变异与神经胶质瘤相关性的病例对照研究进行了荟萃分析，并进一步进行了基于种族和对照来源的亚组分析。确定了截至 2012 年 5 月的合格研究。
结果
共纳入了 4 项病例对照研究，包括 1439 例病例和 2564 例对照，进行了分析。总体数据表明，XRCC1 Arg280His 多态性与神经胶质瘤风险之间无显著相关性（His 对 Arg：OR=1.05；95%CI=0.88-1.25；His/His 对 Arg/Arg：OR=1.42；95%CI=0.87-2.29；显性模型：OR=1.00；95%CI=0.82-1.22；隐性模型：OR=1.41；95%CI=0.88-2.25）。同样，在基于种族和对照来源的亚组分析中，也未观察到相关性。
结论
本研究结果未能提示 XRCC1 Arg280His 多态性与神经胶质瘤风险之间存在关联。需要进一步进行大型且设计良好的研究来证实这一结论。
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