Li Jiang, Qu Qiang, Qu Jian, Luo Wei-Ming, Wang Shang-Yuan, He You-Zhi, Luo Qi-Shan, Xu Yu-Xia, Wang Yong-Fu
Department of Clinical Laboratory, Hunan Provincial People's Hospital, Changsha, 410005, People's Republic of China.
Med Oncol. 2014 Oct;31(10):186. doi: 10.1007/s12032-014-0186-2. Epub 2014 Sep 23.
The pathogenesis of glioma remains largely unknown now. It has been suggested that the X-ray cross-complementing group 1 (XRCC1) gene may influence the capacity to repair DNA damage leading to an increased gliomas susceptibility. This study aimed to evaluate the relationship between XRCC1 polymorphisms and glioma risk. Genotypes were assessed in 368 Chinese glioma patients and 346 healthy controls. XRCC1 Arg194Trp (rs1799782), Arg280His (rs25489) and Arg399Gln (rs25487) and three additional polymorphisms were directly sequenced. The frequency of Arg280His A allele was significant lower in glioma group than in healthy controls [9.6 vs 16%, OR=0.60 (0.46-0.80), P<0.001]; the frequencies of GA or AA genotypes were different in two groups (16.6 vs 22.8%, 1.3 vs 4.7%). The frequency of Arg399Gln A allele was significant higher in glioma group than in healthy controls [38.7 vs 30.1%, OR=1.29 (1.11-1.49), P=0.001]; the frequencies of GA or AA genotypes were different in two groups (45.4 vs 38.2%, 16 vs 10.9%). This study demonstrates that the rs25489 (Arg280His) and Arg399Gln (rs25487) polymorphisms in XRCC1 gene might influence the risk of developing glioma in Chinese population.
目前，胶质瘤的发病机制在很大程度上仍不清楚。有人提出，X射线交叉互补基因1（XRCC1）可能会影响DNA损伤修复能力，从而增加患胶质瘤的易感性。本研究旨在评估XRCC1基因多态性与胶质瘤风险之间的关系。对368例中国胶质瘤患者和346例健康对照者进行了基因分型评估。对XRCC1基因的Arg194Trp（rs1799782）、Arg280His（rs25489）和Arg399Gln（rs25487）以及另外三个多态性位点进行了直接测序。胶质瘤组中Arg280His A等位基因的频率显著低于健康对照组[9.6%对16%，比值比（OR）=0.60（0.46 - 0.80），P<0.001]；两组中GA或AA基因型的频率不同（16.6%对22.8%，1.3%对4.7%）。胶质瘤组中Arg399Gln A等位基因的频率显著高于健康对照组[38.7%对30.1%，OR = 1.29（1.11 - 1.49），P = 0.001]；两组中GA或AA基因型的频率不同（45.4%对38.2%，16%对10.9%）。本研究表明，XRCC1基因中的rs25489（Arg280His）和Arg399Gln（rs25487）多态性可能会影响中国人群患胶质瘤的风险。
