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Expert Rev Endocrinol Metab. 2013 Jan;8(1):71-79. doi: 10.1586/eem.12.73.
2
The Impact of Obesity on the Incidence of Type 2 Diabetes Among Women With Polycystic Ovary Syndrome.肥胖对多囊卵巢综合征妇女 2 型糖尿病发病率的影响。
Diabetes Care. 2019 Apr;42(4):560-567. doi: 10.2337/dc18-1738. Epub 2019 Jan 31.
3
Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics.多囊卵巢综合征肥胖特征：病因、治疗和遗传学。
Metabolism. 2019 Mar;92:108-120. doi: 10.1016/j.metabol.2018.11.002. Epub 2018 Nov 13.
4
Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression.多囊卵巢综合征中种族、肥胖与葡萄糖耐量受损及 2 型糖尿病患病率的关系：系统评价与荟萃回归分析。
Hum Reprod Update. 2018 Jul 1;24(4):455-467. doi: 10.1093/humupd/dmy007.
5
Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences.多囊卵巢综合征（PCOS）：长期代谢后果。
Metabolism. 2018 Sep;86:33-43. doi: 10.1016/j.metabol.2017.09.016. Epub 2017 Oct 10.
6
INSULIN RESISTANCE AND POLYCYSTIC OVARY SYNDROME IN A CHINESE POPULATION.中国人群中的胰岛素抵抗与多囊卵巢综合征
Endocr Pract. 2017 Jul 6. doi: 10.4158/EP171849.OR.
7
Chinese Herbal Medicine for the Optimal Management of Polycystic Ovary Syndrome.中药治疗多囊卵巢综合征的优化管理。
Am J Chin Med. 2017;45(3):405-422. doi: 10.1142/S0192415X17500252. Epub 2017 Mar 30.
8
Associations of insulin receptor and insulin receptor substrates genetic polymorphisms with polycystic ovary syndrome: A systematic review and meta-analysis.胰岛素受体及胰岛素受体底物基因多态性与多囊卵巢综合征的关联：一项系统评价与荟萃分析
J Obstet Gynaecol Res. 2016 Jul;42(7):844-54. doi: 10.1111/jog.13002. Epub 2016 Apr 20.
9
MicroRNAs Related to Polycystic Ovary Syndrome (PCOS).多囊卵巢综合征相关的 microRNAs（miRNAs）。
Genes (Basel). 2014 Aug 25;5(3):684-708. doi: 10.3390/genes5030684.
10
Characterization of serum microRNAs profile of PCOS and identification of novel non-invasive biomarkers.多囊卵巢综合征血清微小RNA谱的特征分析及新型非侵入性生物标志物的鉴定。
Cell Physiol Biochem. 2014;33(5):1304-15. doi: 10.1159/000358698. Epub 2014 Apr 28.

miRNA-135a 结合位点单核苷酸多态性与 IRS2 靶向基因与 PCOS 的多种临床特征相关：中国女性的研究。

Single nucleotide polymorphisms in binding site of miRNA-135a and targeted gene IRS2 are correlated with multiple clinical features of PCOS: A study in Chinese women.

机构信息

NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Hospital, Guangzhou, Guangdong, China.

Dongguan Institute of Reproduction and Genetics, Dongguan Maternal and Children Health Hospital, Dongguan, Guangdong, China.

出版信息

Technol Health Care. 2022;30(S1):71-80. doi: 10.3233/THC-228007.

DOI:10.3233/THC-228007
PMID:35124585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9028752/
Abstract

BACKGROUND

The etiology of polycystic ovary syndrome (PCOS) remains unclear with highly heterogeneous clinical manifestations, recently growing evidence revealing genetic variants play a crucial part in its pathogenesis.

OBJECTIVE

This study aimed to examine the correlation between SNPs in miRNA-135a's binding site of targeted gene IRS2 and clinical manifestations of PCOS in Chinese females.

METHOD

A total of 126 Chinese women with PCOS and 109 healthy women were enrolled, divided into 4 groups based on different clinical features of hyperandrogenemia (HA), insulin resistance (IR), polycystic ovary morphology (PCOM) and obesity. We analyzed 2 single nucleotide polymorphisms (SNPs) of the IRS2 gene (rs2289046 and rs1865434) and clinical features' laboratory measurements such as sex hormone, fasting plasma glucose (FPG), fasting plasma insulin (FINS).

RESULTS

Located in miRNA-135a binding site of IRS2 gene, the rs2289046's triple genotypes distribution showed a significant difference between PCOS/control group and PCOM/non-PCOM group (P< 0.05) while the rs1865434's triple genotype distribution showed a significant difference between obesity/non-obesity group (P< 0.05).

CONCLUSION

The results revealed the two SNPs as rs2289046 and rs1865434 in the IRS-2 binding region of miRNA-135a have correlations with the clinical features of PCOS in Chinese population.

摘要

背景

多囊卵巢综合征（PCOS）的病因尚不清楚，其临床表现高度异质，最近越来越多的证据表明遗传变异在其发病机制中起着至关重要的作用。

目的

本研究旨在探讨 miRNA-135a 靶向基因 IRS2 结合位点的 SNP 与中国女性 PCOS 临床表型的相关性。

方法

共纳入 126 例 PCOS 女性和 109 例健康女性，根据高雄激素血症（HA）、胰岛素抵抗（IR）、多囊卵巢形态（PCOM）和肥胖的不同临床特征分为 4 组。我们分析了 IRS2 基因的 2 个单核苷酸多态性（SNPs）（rs2289046 和 rs1865434）和临床特征实验室测量值，如性激素、空腹血糖（FPG）、空腹胰岛素（FINS）。

结果

位于 IRS2 基因的 miRNA-135a 结合位点，rs2289046 的三基因型分布在 PCOS/对照组和 PCOM/非 PCOM 组之间存在显著差异（P<0.05），而 rs1865434 的三基因型分布在肥胖/非肥胖组之间存在显著差异（P<0.05）。

结论

结果表明，miRNA-135a 的 IRS-2 结合区的两个 SNP（rs2289046 和 rs1865434）与中国人群 PCOS 的临床特征相关。