提高腰椎手术中骨移植替代技术的临床证据。
Improving the clinical evidence of bone graft substitute technology in lumbar spine surgery.
机构信息
Department of Orthopaedic Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Department of Orthopaedic Surgery, UCLA Comprehensive Spine Center, Santa Monica, California.
出版信息
Global Spine J. 2012 Dec;2(4):239-48. doi: 10.1055/s-0032-1315454. Epub 2012 Oct 9.
Abstract
Bone graft substitutes have been used routinely for spine fusion for decades, yet clinical evidence establishing comparative data remains sparse. With recent scrutiny paid to the outcomes, complications, and costs associated with osteobiologics, a need to improve available data guiding efficacious use exists. We review the currently available clinical literature, studying the outcomes of various biologics in posterolateral lumbar spine fusion, and establish the need for a multicenter, independent osteobiologics registry.
摘要
几十年来，骨移植替代物已被常规用于脊柱融合，但仍缺乏临床证据来建立对比数据。随着最近对与骨生物材料相关的结果、并发症和成本的关注，需要改进现有的数据来指导其有效使用。我们回顾了目前可用的临床文献，研究了各种生物材料在后外侧腰椎融合中的结果，并确定需要建立一个多中心、独立的骨生物材料登记处。
相似文献
1
Improving the clinical evidence of bone graft substitute technology in lumbar spine surgery.
Global Spine J. 2012 Dec;2(4):239-48. doi: 10.1055/s-0032-1315454. Epub 2012 Oct 9.
2
Experimental posterolateral lumbar spinal fusion with a demineralized bone matrix gel.
Spine (Phila Pa 1976). 1998 Jan 15;23(2):159-67. doi: 10.1097/00007632-199801150-00003.
3
Bone substitutes and expanders in Spine Surgery: A review of their fusion efficacies.
Int J Spine Surg. 2016 Sep 22;10:33. doi: 10.14444/3033. eCollection 2016.
4
New formulations of demineralized bone matrix as a more effective graft alternative in experimental posterolateral lumbar spine arthrodesis.
Spine (Phila Pa 1976). 1999 Apr 1;24(7):637-45. doi: 10.1097/00007632-199904010-00005.
5
Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 16: bone graft extenders and substitutes as an adjunct for lumbar fusion.
J Neurosurg Spine. 2014 Jul;21(1):106-32. doi: 10.3171/2014.4.SPINE14325.
6
Bone Substitute Options for Spine Fusion in Patients With Spine Trauma-Part I: Fusion Biology, Autografts, Allografts, Demineralized Bone Matrix, and Ceramics.
Korean J Neurotrauma. 2023 Dec 19;19(4):446-453. doi: 10.13004/kjnt.2023.19.e62. eCollection 2023 Dec.
7
The use of coralline hydroxyapatite with bone marrow, autogenous bone graft, or osteoinductive bone protein extract for posterolateral lumbar spine fusion.
Spine (Phila Pa 1976). 1999 Feb 15;24(4):320-7. doi: 10.1097/00007632-199902150-00003.
8
Graft options in posterolateral and posterior interbody lumbar fusion.
Spine (Phila Pa 1976). 2010 Aug 1;35(17):1629-39. doi: 10.1097/BRS.0b013e3181d25803.
9
Comparison of Healos/bone marrow to INFUSE(rhBMP-2/ACS) with a collagen-ceramic sponge bulking agent as graft substitutes for lumbar spine fusion.
Spine (Phila Pa 1976). 2005 May 1;30(9):1001-7; discussion 1007. doi: 10.1097/01.brs.0000160997.91502.3b.
10
Allogeneic mesenchymal progenitor cells for posterolateral lumbar spine fusion in sheep.
Spine J. 2014 Mar 1;14(3):435-44. doi: 10.1016/j.spinee.2013.09.048. Epub 2013 Oct 23.
引用本文的文献
1
Decorticating and Grafting Technique in Posterior Instrumented Spinal Fusion for Idiopathic Scoliosis Correction Surgery.
Cureus. 2025 Jul 19;17(7):e88313. doi: 10.7759/cureus.88313. eCollection 2025 Jul.
2
Bone fusion materials: past, present, and future.
Asian Spine J. 2025 Feb 4. doi: 10.31616/asj.2024.0520.
3
Does Bone Morphogenetic Protein Use Reduce Pseudarthrosis Rates in Single-Level Transforaminal Lumbar Interbody Fusion Surgeries?
Int J Spine Surg. 2024 May 6;18(2):207-216. doi: 10.14444/8590.
4
Finite element biomechanical analysis of 3D printed intervertebral fusion cage in osteoporotic population.
BMC Musculoskelet Disord. 2024 Feb 12;25(1):129. doi: 10.1186/s12891-024-07221-7.
5
Cellular Bone Matrix in Spine Surgery - Are They Worth the Risk: A Systematic Review.
Global Spine J. 2024 Apr;14(3):1070-1081. doi: 10.1177/21925682231205099. Epub 2023 Sep 29.
6
The benefit of antibiotic-combined Mg-hydroxyapatite bone graft substitute over autologous bone for surgical site infection prevention in posterolateral spinal fusion: a retrospective cohort study.
Ann Med Surg (Lond). 2023 Apr 27;85(6):2341-2347. doi: 10.1097/MS9.0000000000000728. eCollection 2023 Jun.
7
Biomechanical evaluation of different sizes of 3D printed cage in lumbar interbody fusion-a finite element analysis.
BMC Musculoskelet Disord. 2023 Feb 1;24(1):85. doi: 10.1186/s12891-023-06201-7.
8
Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study.
Front Bioeng Biotechnol. 2022 Nov 17;10:1050495. doi: 10.3389/fbioe.2022.1050495. eCollection 2022.
9
Fusion assessment in standalone lateral lumbar interbody fusion: 3D-printed titanium versus polyetheretherketone (PEEK) cages.
J Spine Surg. 2022 Sep;8(3):323-332. doi: 10.21037/jss-22-17.
10
Bone Morphogenetic Protein in Anterior Lumbar Interbody Fusions: A Propensity-Matched Medicare Outcome Analysis.
Int J Spine Surg. 2022 Jun 14;16(4):706-13. doi: 10.14444/8301.
本文引用的文献
1
Evaluation of autologous platelet concentrate for intertransverse lumbar fusion.
Eur Spine J. 2011 Aug;20 Suppl 3(Suppl 3):361-6. doi: 10.1007/s00586-011-1904-5. Epub 2011 Jul 23.
2
A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned.
Spine J. 2011 Jun;11(6):471-91. doi: 10.1016/j.spinee.2011.04.023.
3
Hybrid grafting using bone marrow aspirate combined with porous β-tricalcium phosphate and trephine bone for lumbar posterolateral spinal fusion: a prospective, comparative study versus local bone grafting.
Spine (Phila Pa 1976). 2012 Feb 1;37(3):E174-9. doi: 10.1097/BRS.0b013e3182269d64.
4
Uni- and bilateral instrumented posterolateral fusion of the lumbar spine with local bone grafting: a prospective study with a 2-year follow-up.
Spine (Phila Pa 1976). 2011 Dec 15;36(26):E1744-8. doi: 10.1097/BRS.0b013e31821f50de.
5
Inflammatory characteristics of rhBMP-2 in vitro and in an in vivo rodent model.
Spine (Phila Pa 1976). 2011 Feb 1;36(3):E149-54. doi: 10.1097/BRS.0b013e3181f2d1ec.
6
One, two-, and three-level instrumented posterolateral fusion of the lumbar spine with a local bone graft: a prospective study with a 2-year follow-up.
Spine (Phila Pa 1976). 2011 Aug 1;36(17):1392-6. doi: 10.1097/BRS.0b013e3181f40e69.
7
Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems.
Am J Sports Med. 2011 Feb;39(2):266-71. doi: 10.1177/0363546510387517. Epub 2010 Nov 4.
8
Histopathologic inflammatory response induced by recombinant bone morphogenetic protein-2 causing radiculopathy after transforaminal lumbar interbody fusion.
Spine J. 2010 Sep;10(9):e1-6. doi: 10.1016/j.spinee.2010.06.020.
9
Efficacy of silicate-substituted calcium phosphate ceramic in posterolateral instrumented lumbar fusion.
Spine (Phila Pa 1976). 2010 Sep 15;35(20):E1058-63. doi: 10.1097/BRS.0b013e3181df196f.
10
Fusion rates and subsidence of morselized local bone grafted in titanium cages in posterior lumbar interbody fusion using quantitative three-dimensional computed tomography scans.
Spine (Phila Pa 1976). 2010 Jul 1;35(15):1460-5. doi: 10.1097/BRS.0b013e3181c4baf5.
Zotero 插件