来自暗褐网孢牛肝菌的二氧三环和氧杂双环多酮。

Dioxatricyclic and oxabicyclic polyketides from Trichocladium opacum.

机构信息

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100190, People's Republic of China.

出版信息

J Nat Prod. 2014 Jan 24;77(1):9-14. doi: 10.1021/np4004799. Epub 2013 Dec 19.

DOI:10.1021/np4004799

PMID:24354429

Abstract

Five new polyketides, trichocladinols D-H (1-5) with dioxatricyclic (1-3) and oxabicyclic (4 and 5) skeletons, and the known massarilactone C (6) were isolated from the solid-substrate fermentation cultures of the ascomycete fungus Trichocladium opacum. The structures of 1-5 were determined mainly by NMR experiments, and 1, 3, and 4 were confirmed by X-ray crystallography. The absolute configurations of 1 and 3 were assigned by X-ray crystallography using Cu Kα radiation, whereas that of C-5 in 2 and 4 was deduced via the circular dichroism (CD) data. Compounds 2-4 showed weak cytotoxicity against the human tumor cell lines A549, HCT116, and SW480.

摘要

从曲霉属真菌密粘褶菌的固体基质发酵培养物中分离得到五个新的聚酮化合物，分别为 Trichocladinols D-H（1-5），具有二氧三环（1-3）和氧杂双环（4 和 5）骨架，以及已知的 Massarilactone C（6）。化合物 1-5 的结构主要通过 NMR 实验确定，化合物 1、3 和 4 通过 X 射线晶体学得到确认。化合物 1 和 3 的绝对构型通过 Cu Kα 辐射的 X 射线晶体学确定，而化合物 2 和 4 中 C-5 的构型则通过圆二色性（CD）数据推断得出。化合物 2-4 对人肿瘤细胞系 A549、HCT116 和 SW480 表现出较弱的细胞毒性。