Lin Jie, Wang Renlei, Xu Guohua, Ding Zhengfeng, Zhu Xueshen, Li Erwei, Liu Ling
Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry, Jiangsu Second Normal University, Nanjing, PR China.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.
J Antibiot (Tokyo). 2017 Jun;70(6):743-746. doi: 10.1038/ja.2017.5. Epub 2017 Feb 15.
Leptosphaerins H and I (1 and 2), two new xanthone derivatives, and six known compounds, leptosphaerin F (3), monodictysin B (4), norlichexanthone (5), leptosphaerin D (6), moniliphenone (7) and emodinbianthrone (8) have been isolated from a scale-up fermentation of the ascomycete fungus Leptosphaeria sp. Their structures were primarily elucidated by interpretation of NMR spectroscopic data. The absolute configuration of 1 was assigned using the modified Mosher method, whereas that of C-8a in 2 was determined via the CD data. Compound 6 showed modest cytotoxicity against a panel of three human tumor cell lines.
从子囊菌Leptosphaeria sp.的放大发酵物中分离出了细交链孢菌酮酸H和I（1和2）这两种新的呫吨酮衍生物，以及六种已知化合物，即细交链孢菌酮酸F（3）、单隔黄原酮B（4）、降斑点黄原酮（5）、细交链孢菌酮酸D（6）、念珠菌素（7）和大黄素双蒽酮（8）。它们的结构主要通过核磁共振光谱数据的解析得以阐明。化合物1的绝对构型采用改良的莫舍尔方法确定，而化合物2中C-8a的绝对构型则通过圆二色光谱数据确定。化合物6对一组三种人类肿瘤细胞系显示出适度的细胞毒性。
