da Silva Fernanda Gomes, Horta Lívia Pereira, de Oliveira Faria Raquel, Stehmann Joao Renato, Modolo Luzia Valentina
Grupo de Estudos em Bioquimica de Plantas, Departamento de Botanica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Recent Pat Biotechnol. 2014;8(1):89-101. doi: 10.2174/1872208307666131218124836.
There is a consensus that plants are great sources of metabolites with a broad variety of functions. This is particularly important because plants cannot run away from environmental conditions that can threat their existence. The numerous biological activities exhibited by plant natural products prompted humanity to use such substances or their derivatives for the treatment and/or prevention of diseases. The more we know the flora around the world the higher is the chance to find new lead compounds for the design of more potent drugs or nutraceuticals. This review first deals with Brazilian flora, contextualizing the most studied medicinal species and related patents. It also describes a compilation of relevant works based on the use of stress conditions to enhance the biosynthesis of valuable metabolites in cell cultures, tissue cultures (hairy roots) and whole plants by using native or crop plants around the world.
人们普遍认为，植物是具有多种功能的代谢物的重要来源。这一点尤为重要，因为植物无法逃避可能威胁其生存的环境条件。植物天然产物所展现出的众多生物活性促使人类将此类物质或其衍生物用于疾病的治疗和/或预防。我们对世界各地植物群的了解越多，就越有可能找到新的先导化合物，用于设计更有效的药物或营养保健品。本综述首先探讨巴西植物群，介绍研究最多的药用植物种类及相关专利。它还描述了一系列相关研究成果，这些研究利用胁迫条件，通过世界各地的本土植物或农作物，增强细胞培养、组织培养（毛状根）和整株植物中有价值代谢物的生物合成。
