Janket Sok-Ja, Baird Alison E, Jones Judith A, Jackson Elizabeth A, Surakka Markku, Tao Wen, Meurman Jukka H, Van Dyke Thomas E
Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.
J Clin Periodontol. 2014 Feb;41(2):131-40. doi: 10.1111/jcpe.12192. Epub 2013 Dec 10.
To test whether the number of teeth, an inverse proxy for composite oral infection scores is associated with better survival.
The Kuopio Oral Health and Heart study initiated a case-control study in 1995-1996 consisting of 256 consecutive coronary artery disease patients and 250 age and gender-matched controls. We appended the mortality data and formulated a longitudinal study. By May 31st, 2011, 124 mortalities had occurred and 80 of which were of cardiovascular origin. Using Cox proportional hazards models, we assessed the association of the teeth group (Teethgrp) - consisting of 10 teeth - with cardiovascular and all-cause mortality after 15.8 years of median follow-up.
In multivariate models, with the edentulous state as reference, one level increase in Teethgrp was associated with significantly increased survival from cardiovascular disease (CVD) mortality with a Hazard Ratio (HR) 0.73, p-value = 0.02 but not with all-cause mortality (HR = 0.87, p = 0.13). The findings were not mediated by C-reactive protein (CRP) levels ≥3 mg/L or by median fibrinogen levels, but were mediated by CRP levels >5 mg/L.
Each increment of 10 teeth from the edentulous state was associated with a 27% improved CVD survival, independent of low-grade systemic inflammation.
检验牙齿数量（口腔综合感染评分的反向指标）是否与更好的生存率相关。
库奥皮奥口腔健康与心脏研究于1995 - 1996年开展了一项病例对照研究，纳入了256例连续的冠状动脉疾病患者以及250例年龄和性别匹配的对照。我们补充了死亡率数据并开展了一项纵向研究。截至2011年5月31日，发生了124例死亡，其中80例源于心血管疾病。使用Cox比例风险模型，在中位随访15.8年后，我们评估了由10颗牙齿组成的牙齿组（Teethgrp）与心血管疾病死亡率和全因死亡率之间的关联。
在多变量模型中，以无牙状态为参照，Teethgrp每增加一个等级，心血管疾病（CVD）死亡率的生存率显著增加，风险比（HR）为0.73，p值 = 0.02，但与全因死亡率无关（HR = 0.87，p = 0.13）。这些发现不是由C反应蛋白（CRP）水平≥3 mg/L或纤维蛋白原中位水平介导的，而是由CRP水平>5 mg/L介导的。
从无牙状态开始，每增加10颗牙齿与心血管疾病生存率提高27%相关，且独立于低度全身炎症。
