Moss Raymond L
Institute for Energy and Transport, Joint Research Centre, European Commission, Westerduinweg 3, 1755 LE, Petten, The Netherlands.
Appl Radiat Isot. 2014 Jun;88:2-11. doi: 10.1016/j.apradiso.2013.11.109. Epub 2013 Dec 4.
The first BNCT trials took place in the USA in the early 1960's, yet BNCT is still far from mainstream medicine. Nonetheless, in recent years, reported results in the treatment of head and neck cancer and recurrent glioma, coupled with the progress in developing linear accelerators specifically for BNCT applications, have given some optimism to the future of BNCT. This article provides a brief reminder on the ups and downs of the history of BNCT and supports the view that controlled and prospective clinical trials with a modern design will make BNCT an evidence-based treatment modality within the coming decade.
首次硼中子俘获治疗（BNCT）试验于20世纪60年代初在美国进行，但BNCT仍远未成为主流医学。尽管如此，近年来，在头颈部癌症和复发性神经胶质瘤治疗方面报告的结果，以及专门为BNCT应用开发直线加速器所取得的进展，给BNCT的未来带来了一些乐观情绪。本文简要回顾了BNCT历史的起伏，并支持这样一种观点，即采用现代设计的对照前瞻性临床试验将使BNCT在未来十年内成为一种基于证据的治疗方式。
