硼中子俘获治疗（BNCT）在芬兰：20 年经验后的技术和物理展望。

Boron neutron capture therapy (BNCT) in Finland: technological and physical prospects after 20 years of experiences.

机构信息

Department of Physics, University of Helsinki, Finland.

出版信息

Phys Med. 2013 May;29(3):233-48. doi: 10.1016/j.ejmp.2012.04.008. Epub 2012 May 20.

DOI:10.1016/j.ejmp.2012.04.008

Abstract

Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.

摘要

硼中子俘获治疗（BNCT）是一种二元放射治疗方法，旨在治疗某些恶性肿瘤患者。迄今为止，芬兰 BNCT 设施已经在各种正在进行和过去的临床试验中进行了超过 300 次治疗。在本技术评论中，我们讨论了我们在医学物理学领域的研究工作，为芬兰 BNCT 患者治疗奠定了基础，并探讨了未来进一步发展和优化该方法的可能性。因此，本文描述了以下几个方面：中子源、束剂量学、治疗计划、硼成像和定量，以及最终检测 BNCT 对患者疗效和影响的可能性。