Zhang Tiantian, Fu Qianqian, Gao Dalin, Ge Liyan, Sun Lin, Zhai Qiongli
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China; Sino-American Diagnostic and Therapeutic Center for Hematological Malignancies, Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China; Sino-American Diagnostic and Therapeutic Center for Hematological Malignancies, Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China; Department of Pathology, General Hospital of Tianjin, Dagang, Oilfield, China.
Pathol Res Pract. 2014 Feb;210(2):69-73. doi: 10.1016/j.prp.2013.11.009. Epub 2013 Nov 28.
Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus that asymptomatically infects more than 90% of the world's population. The exact mechanism of EBV in oncogenesis is an area of active debate. However, EBV has been implicated in the pathogenesis of several kinds of lymphomas and lymphoproliferative disorders, including B-, T- and NK-cell derived. Subsequent studies have proven that the EBV gene expression product plays an activating and/or promoting role on lymphomagenesis, and paves the way for novel cellular therapies of EBV-associated lymphomas. This review concentrates on the pathology, morphology, treatment and prognosis of EBV-associated lymphomas in the 2008 WHO classification of tumors of hematopoietic and lymphoma tissues.
爱泼斯坦-巴尔病毒（EBV）是一种普遍存在的γ疱疹病毒，全球超过90%的人口都曾无症状感染过该病毒。EBV在肿瘤发生中的具体机制是一个仍在积极探讨的领域。然而，EBV已被证实与多种淋巴瘤和淋巴增殖性疾病的发病机制有关，包括B细胞、T细胞和NK细胞来源的疾病。后续研究证明，EBV基因表达产物在淋巴瘤发生过程中发挥激活和/或促进作用，为EBV相关淋巴瘤的新型细胞疗法铺平了道路。本综述聚焦于2008年世界卫生组织造血与淋巴瘤组织肿瘤分类中EBV相关淋巴瘤的病理学、形态学、治疗及预后。
