Qin Changfei, Huang Yuhua, Feng Yanfen, Li Min, Guo Na, Rao Huilan
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, People's Republic of China.
Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.
Diagn Pathol. 2018 Feb 27;13(1):17. doi: 10.1186/s13000-018-0693-0.
The clinicopathological features and Epstein-Barr virus (EBV) infection status of lymphoma in children and adolescents in South China is under-researched. South China is a well-known high-incidence area of EBV-associated nasopharyngeal carcinoma.
A cohort of 662 consecutive children and adolescents' lymphomas was retrospectively analyzed and Epstein-Barr virus encoded RNAs (EBERs) in situ hybridization was performed to detect the EBV infection.
The majority (501/662, 75.7%) of lymphomas in children and adolescents was Non-Hodgkin lymphoma (NHL). One hundred sixty one cases (24.3%) were Hodgkin lymphoma (HL). Of the NHL, precursor cell lymphoma, mature B-cell lymphoma and peripheral T/NK-cell lymphoma accounted for 32.0%, 41.1% and 26.9% respectively. The five common subtypes were lymphoblastic lymphoma (32.0%), Burkitt lymphoma (BL) (21.0%), anaplastic large-cell lymphoma (ALCL) (14.2%), diffuse large B-cell lymphoma (DLBCL) (13.8%) and extranodal NK/T-cell lymphoma, nasal type (ENKTCL) (6.2%). EBV infection was detected in 58.9% classical Hodgkin lymphomas (CHLs), 21.4% mature B-cell lymphomas and 52.4% peripheral T/NK-cell lymphomas. Moreover, EBV was associated with high grade NHL including ENKTCL (100.0%), BL (30.5%) and DLBCL (17.6%).
The high proportion of peripheral T/NK-cell lymphomas in children and adolescents in South China are presented in this study and compared to western countries due to the high percentage of ENKTCL. ENKTCL is firmly associated with EBV infection, while more than half of HL, a portion of BL and DLBCL are related to EBV infection. This study conclusively demonstrates that EBV infection is more prevalent in children and adolescents with lymphomas in South China compared to western countries.
中国南方儿童及青少年淋巴瘤的临床病理特征及EB病毒（EBV）感染状况研究较少。中国南方是著名的EBV相关鼻咽癌高发地区。
回顾性分析662例连续的儿童及青少年淋巴瘤患者队列，并采用EB病毒编码RNA（EBER）原位杂交检测EBV感染情况。
儿童及青少年淋巴瘤中大多数（501/662，75.7%）为非霍奇金淋巴瘤（NHL）。161例（24.3%）为霍奇金淋巴瘤（HL）。在NHL中，前体细胞淋巴瘤、成熟B细胞淋巴瘤和外周T/NK细胞淋巴瘤分别占32.0%、41.1%和26.9%。五种常见亚型为淋巴母细胞淋巴瘤（32.0%）、伯基特淋巴瘤（BL）（21.0%）、间变性大细胞淋巴瘤（ALCL）（14.2%）、弥漫性大B细胞淋巴瘤（DLBCL）（13.8%）和鼻型结外NK/T细胞淋巴瘤（ENKTCL）（6.2%）。在58.9%的经典型霍奇金淋巴瘤（CHL）、21.4%的成熟B细胞淋巴瘤和52.4%的外周T/NK细胞淋巴瘤中检测到EBV感染。此外，EBV与高级别NHL相关，包括ENKTCL（100.0%）、BL（30.5%）和DLBCL（17.6%）。
本研究呈现了中国南方儿童及青少年外周T/NK细胞淋巴瘤的高比例情况，与西方国家相比，ENKTCL的比例较高。ENKTCL与EBV感染密切相关，而超过一半的HL、部分BL和DLBCL与EBV感染有关。本研究确凿地表明，与西方国家相比，中国南方淋巴瘤儿童及青少年中EBV感染更为普遍。
