Protsenko V A, Kharchenko V Z, Kolesnikov Iu N, Spitsyn I F, Egorychev V E
Farmakol Toksikol. 1987 Jan-Feb;50(1):64-6.
It was shown in Wistar male rats that the development of tourniquet shock was followed by an increase of proteolytic activity in the blood by 3 times, activity of aspartate aminotransferase (AST) by 3 times, that of alanine aminotransferase (ALT) by 6 times, contents of urea and residual nitrogen by 2.5-3 times; level of alpha 1-protease inhibitor (alpha 1-PI) decreased by 4 times and that of alpha 2-macroglobulin (alpha 2MG) by 2.5 times. At administration of contrykal (10,000 U/kg) proteolytic activity increased only by 32.5%, content of alpha 1-PI decreased only by 10-20% and level of alpha 2-MG did not differ from that in healthy animals. Activity of AST and ALT remained high, and contents of urea and residual nitrogen were near-normal.
在雄性Wistar大鼠中发现，止血带休克发生后，血液中的蛋白水解活性增加了3倍，天冬氨酸转氨酶（AST）活性增加了3倍，丙氨酸转氨酶（ALT）活性增加了6倍，尿素和残余氮含量增加了2.5至3倍；α1-蛋白酶抑制剂（α1-PI）水平降低了4倍，α2-巨球蛋白（α2MG）水平降低了2.5倍。给予康力舒（10,000 U/kg）后，蛋白水解活性仅增加32.5%，α1-PI含量仅降低10-20%，α2-MG水平与健康动物无异。AST和ALT活性仍然很高，尿素和残余氮含量接近正常。
