Kharchenko V Z, Protsenko V A
Farmakol Toksikol. 1977 Sep-Oct;40(5):609-13.
By studying the ECG findings, dynamic changes of the body temperature, the edemas size in the tourniquet-compressed limbs, vascular permeability of the skin, general condition and survival rate on a model of post-ischemic toxemia in albino rats it was found that the serum containing antibodies to pancreatic kallikrein (200 gamma/ml), when introduced parenterally (1 ml per 100 g of the mass), increases the survival time of the animals and prevents the development of gangrene in the ischemic limbs. The curative effect of the antikallikrein serum resembles the action of ingitril, a polyvalent inhibitor (1.5 Un. per 100 g of the mass). The antitryptic serum employed in analogous doses stands by its action close to the normal rabbit's serum.
通过对白化大鼠缺血后毒血症模型的心电图表现、体温动态变化、止血带压迫肢体的水肿大小、皮肤血管通透性、一般状况和存活率进行研究，发现含有抗胰激肽释放酶抗体的血清（200γ/ml），经肠胃外给药（每100g体重1ml）时，可延长动物存活时间，并防止缺血肢体发生坏疽。抗激肽释放酶血清的治疗效果类似于英吉利，一种多价抑制剂（每100g体重1.5单位）的作用。以类似剂量使用的抗胰蛋白酶血清，其作用与正常兔血清相近。
