Protsenko V A, Opryshko V V, Nesterov E N, Bogadel'nikov I V, Kharchenko V Z
Farmakol Toksikol. 1981 Sep-Oct;44(5):589-93.
The development of dysenteric intoxication in rabbits led to an abrupt increase in the blood activity of proteolytic enzymes. This increase was accompanied by the reduced content of alpha 1-antitrypsin, and that of rapid and slow kallikrein inhibitor. Meanwhile there occurred a remarkable decrease in blood serum ability to bind chymotrypsin and kallikrein, and diminution of alpha 2-macroglobulin level. Trypsin, binding by blood serum did not undergo any substantial changes. In these conditions, the permeability of pulmonary vessels drastically rose and surface activity of the washing off dropped. The pathomorphological alterations in the lungs corresponded with the appearance of the "shock lung". Contrykal normalized the blood content of proteolytic enzymes and inhibitors, as well as that of the bronchoalveolar washing off, averted the development of gross pathomorphological alterations, exerting no appreciable effect on the surface activity of the bronchoalveolar washing off.
家兔痢疾性中毒的发展导致蛋白水解酶的血液活性急剧增加。这种增加伴随着α1-抗胰蛋白酶含量的降低，以及快速和慢速激肽释放酶抑制剂含量的降低。与此同时，血清结合糜蛋白酶和激肽释放酶的能力显著下降，α2-巨球蛋白水平降低。血清结合的胰蛋白酶没有发生任何实质性变化。在这些情况下，肺血管通透性急剧升高，冲洗液的表面活性下降。肺部的病理形态学改变与“休克肺”的出现相对应。抗蛇毒血清使蛋白水解酶和抑制剂的血液含量以及支气管肺泡冲洗液的含量恢复正常，避免了明显的病理形态学改变的发展，对支气管肺泡冲洗液的表面活性没有明显影响。
