Mintziori Gesthimani, Goulis Dimitrios G, Gialamas Eleftherios, Dosopoulos Konstantinos, Zouzoulas Dimitrios, Gitas George, Venetis Christos A, Toulis Konstantinos A, Kolibianakis Efstratios M, Tarlatzis Basil C
Unit of Reproductive Endocrinology and Unit of Human Reproduction, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Gynecol Obstet Invest. 2014;77(2):84-8. doi: 10.1159/000357193. Epub 2013 Dec 14.
BACKGROUND/AIMS: This study aimed to evaluate the association of thyroid-stimulating hormone (TSH) concentrations and presence of thyroid autoimmunity (TAI) with the live birth rate in euthyroid women undergoing in vitro fertilization (IVF).
This study of retrospective design included 158 euthyroid women (TSH 0.5-4.5 µIU/ml) who underwent IVF from January 2006 to December 2010. Thyroid parameters were measured on day 3 of the previous nontreatment cycle. Women were subgrouped and analyzed according to their TSH concentrations (low: 0.5-2.5 vs. high: 2.6-4.5 µIU/ml) and TAI (present vs. absent).
No difference in the live birth rate was found between the TSH (low: 34.2% vs. high: 36.8%, p = 0.763) or TAI (present: 26.7% vs. absent: 34.3%, p = 0.568) subgroups.
This study found no evidence that increased TSH concentrations or the presence of TAI determined before IVF affect the live birth rate in euthyroid women. A better insight into the role of thyroid function during application of IVF is needed.
背景/目的：本研究旨在评估促甲状腺激素（TSH）浓度及甲状腺自身免疫（TAI）的存在与接受体外受精（IVF）的甲状腺功能正常女性的活产率之间的关联。
这项回顾性研究纳入了2006年1月至2010年12月期间接受IVF的158名甲状腺功能正常的女性（TSH 0.5 - 4.5 μIU/ml）。在前一个非治疗周期的第3天测量甲状腺参数。根据TSH浓度（低：0.5 - 2.5 vs. 高：2.6 - 4.5 μIU/ml）和TAI（存在 vs. 不存在）对女性进行分组并分析。
TSH亚组（低：34.2% vs. 高：36.8%，p = 0.763）或TAI亚组（存在：26.7% vs. 不存在：34.3%，p = 0.568）之间的活产率没有差异。
本研究未发现证据表明IVF前TSH浓度升高或TAI的存在会影响甲状腺功能正常女性的活产率。需要更深入了解IVF应用过程中甲状腺功能的作用。
