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正常人及共济失调毛细血管扩张症成纤维细胞在暴露于60Coγ射线、241Amα粒子或博来霉素后双链断裂的重新连接

Rejoining of double strand breaks in normal human and ataxia-telangiectasia fibroblasts after exposure to 60Co gamma-rays, 241Am alpha-particles or bleomycin.

作者信息

Coquerelle T M, Weibezahn K F, Lücke-Huhle C

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Feb;51(2):209-18. doi: 10.1080/09553008714550711.

DOI:10.1080/09553008714550711
PMID:2435666
Abstract

The rejoining of DNA double strand breaks (dsb) induced by 60Co gamma-rays, 241Am alpha-particles or bleomycin was measured by neutral filter elution. In agreement with their colony-forming ability, ataxia-telangiectasia cells (AT2BE) and normal fibroblasts exhibited similar dsb rejoining capacity following alpha-irradiation, but showed marked differences in the rejoining kinetics of dsb induced by gamma-rays or bleomycin.

摘要

通过中性滤膜洗脱法测定了由60Co γ射线、241Am α粒子或博来霉素诱导的DNA双链断裂（dsb）的重新连接情况。与它们的集落形成能力一致，共济失调毛细血管扩张症细胞（AT2BE）和正常成纤维细胞在α射线照射后表现出相似的dsb重新连接能力，但在γ射线或博来霉素诱导的dsb重新连接动力学方面存在显著差异。

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