Ricciardi Luciana, Edwards Mark J
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Neurotherapeutics. 2014 Jan;11(1):201-7. doi: 10.1007/s13311-013-0246-x.
Functional (psychogenic) movement disorders are a common source of disability and distress. Despite this, little systematic evidence is available to guide treatment decisions. This situation is likely to have been influenced by the "no man's land" that such patients occupy between neurologists and psychiatrists, often with neither side feeling a clear responsibility or ability to direct management. The aim of this narrative review is to provide an overview of the current state of the evidence regarding management of functional movement disorders. This reveals that there is some evidence to support the use of specific forms of cognitive behavioral therapy and physiotherapy. Such treatments may be facilitated in selected patients with the use of antidepressant medication, and may be more effective for those with severe symptoms when given as part of inpatient multidisciplinary rehabilitation. Other treatments, for example hypnosis and transcranial magnetic stimulation, are of interest, but further evidence is required regarding mechanism of effect and long-term benefit. Though prognosis is poor in general, improvement in symptoms is possible in patients with functional movement disorders, and there is a clear challenge to clinicians and therapists involved in their care to conduct and advocate for high-quality clinical trials.
功能性(心因性)运动障碍是导致残疾和痛苦的常见原因。尽管如此,几乎没有系统的证据可用于指导治疗决策。这种情况可能受到这类患者处于神经科医生和精神科医生之间的“无人区”的影响,通常双方都感觉没有明确的责任或能力来指导管理。本叙述性综述的目的是概述功能性运动障碍管理的现有证据状况。这表明有一些证据支持使用特定形式的认知行为疗法和物理疗法。在部分患者中,使用抗抑郁药物可能有助于这些治疗,并且作为住院多学科康复的一部分给予时,对症状严重的患者可能更有效。其他治疗方法,如催眠和经颅磁刺激,也受到关注,但在作用机制和长期益处方面还需要更多证据。尽管总体预后较差,但功能性运动障碍患者的症状有可能改善,参与其护理的临床医生和治疗师面临着开展并倡导高质量临床试验的明确挑战。