Unidad Estratégica de Acción de Bioprospección, Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Heredia, Costa Rica.
Farmacognosia y Biología Vegetal, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional Rosario, Rosario, Argentina.
Planta Med. 2013 Dec;79(18):1749-55. doi: 10.1055/s-0033-1351025. Epub 2013 Dec 19.
From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.
从在一项旨在发现来自拉丁美洲植物的抗真菌化合物的多国 OAS 计划中选择的 Godmania aesculifolia 的甲醇根提取物中，分离并鉴定出了一种新的 chavicol 二糖苷（1）、已知的 3,4-二羟基-2-(3-甲基-2-丁烯-1-基）-3,4-二氢萘-1(2H)-酮（2）和 lapachol（3）。只有 3 对一组临床分离的新型隐球菌（MIC50 在 7.8 和 31.2 µg/mL 之间）表现出相当好的活性，对念珠菌属和非白色念珠菌属念珠菌属也有中等活性。
