Gawande Manoj B, Bonifácio Vasco D B, Luque Rafael, Branco Paula S, Varma Rajender S
REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica (Portugal), Fax: (+351) 21-2948550; current address: Regional Centre of Advanced Technologies and Materials, Faculty of Science, Department of Physical Chemistry, Palacky University, 17. listopadu 12, 771 46 Olomouc (Czech Republic).
ChemSusChem. 2014 Jan;7(1):24-44. doi: 10.1002/cssc.201300485.
In the past decade, alternative benign organic methodologies have become an imperative part of organic syntheses and chemical reactions. The various new and innovative sustainable organic reactions and methodologies using no solvents or catalysts and employing alternative energy inputs such as microwaves, sonication, conventional and room temperature heating conditions, mechanochemical mixing, and high-speed ball milling are discussed in detail. Environmentally benign and pharmaceutically important reactions such as multicomponent, condensation, and Michael addition reactions; ring opening of epoxides; and oxidation and other significant organic reactions are discussed. An overview of benign reactions through solvent- and catalyst-free (SF-CF) chemistry and a critical perspective on emerging synergies between SF-CF organic reactions are discussed.
在过去十年中，替代性良性有机方法已成为有机合成和化学反应不可或缺的一部分。详细讨论了各种新型且创新的可持续有机反应和方法，这些反应和方法不使用溶剂或催化剂，并采用微波、超声、常规和室温加热条件、机械化学混合以及高速球磨等替代能源输入。还讨论了环境友好且具有药学重要性的反应，如多组分反应、缩合反应和迈克尔加成反应；环氧化物的开环反应；以及氧化反应和其他重要的有机反应。本文还讨论了通过无溶剂和无催化剂（SF-CF）化学实现的良性反应概述，以及对SF-CF有机反应之间新兴协同作用的批判性观点。
